Effects of amino acid preparations on the amino acid composition of the liver of rats under subchronic alcohol intoxication
https://doi.org/10.29235/1814-6023-2020-17-3-337-345
Abstract
The effects of complex compositions, containing branched-chain amino acids (BCAA), taurine and tryptophan, on the pool of free amino acids in the liver of rats were studied under the conditions of subchronic alcohol intoxication (SHAI). It was established that SHAI led to the decreased levels of treonine, lysine, oxyproline, arginine, b-alanine, as well as the depletion of the pool of irreplaceable amino acids in the liver of rats. Administration of the composition of BCAA and taurine was found to normalize the ratio of replaceable irreplaceable amino acids, the ratio of glycogenic and ketogenic amino acids, to activate the reaction of nitrogen utilization, and to increase Fisher’s index. The effects of the composition, containing BCAA, taurine and tryptophan, were similar to those of amino acid composition that did not contain tryptophan.
About the Authors
Yu. E. Razvodovsky
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
Yury E. Razvodovsky – Head of the Department
50, Gorky Str., 230009, Grodno
V. Yu. Smirnov
Grodno State Medical University
Belarus
Belarus
Vitaly Yu. Smirnov – Ph. D. (Biol.), Assistant Professor, Senior Researcher
80, Gorky Str., 230009, Grodno
I. N. Semenenya
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
Igor N. Semenenya – D. Sc. (Med.), Professor, Director
50, Gorky Str., 230009, Grodno
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Review
For citations:
Razvodovsky Yu.E., Smirnov V.Yu., Semenenya I.N. Effects of amino acid preparations on the amino acid composition of the liver of rats under subchronic alcohol intoxication. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2020;17(3):337-345. (In Russ.) https://doi.org/10.29235/1814-6023-2020-17-3-337-345
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