Links of pathogenesis of pre- and perinatal damage of the children’s brain

A correlation analysis was made of the relationships between the structural changes in the brain and the content of idiotypic, anti-idiotypic antibodies to the soluble calcium-binding protein of the nervous tissue S100 in the serum of 318 children of the frst year of life with consequences of pre- and perinatal brain damage. We established the conjugation between the structural pathology of the brain, represented by cystic-atrophic changes, calcifcations, glia in the brain substance, periventricular leukomalacia, periventricular cysts, expansion of the ventricular system, congenital malformations of the brain, and the content of idiotypic, anti-idiotypic antibodies to the S100 protein in the serum blood of children 3, 6, 9, 12 months old. The concentration of idiotypic and anti-idiotypic antibodies to the protein of the nervous tissue S100 in the serum reflects the severity of destructive processes in the brain substance. Autoimmune processes are one of the mechanisms that lead to the structural damage to the brain in children with adverse pre- and perinatal factors.

1. Zharnyl’skaya Ye. L. The formation of higher cerebral functions in infants who have undergone perinatal hypoxicischemic brain injury. Abstract of Ph. D. diss. Perm’, 2012. 24 p. (in Russian).

2. Smirnov I. E., Ivanov V. A., Zainiddinova R. S. Perinatal hypoxic lesions of the brain in children. Rossiiskii pediatricheskii zhurnal = Russian Pediatric Journal, 2011, no. 3, pp. 23–28 (in Russian).

3. Devyaltovskaya M. G. Consequences of pre- and perinatal brain damage in children. Minsk, Publishing Center of the Belarusian State University, 2015. 210 p. (in Russian).

4. Kurinczuk J. J., White-Koning M., Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Human Development, 2010, vol. 86, no. 6, pp. 329–338. https://doi.org/10.1016/j.earlhumdev.2010.05.010

5. Shan’ko G. G. Diagnosis and treatment of newborn encephalopathy. Minsk, Belarusian Medical Academy of Postgraduate Education, 2012. 40 p. (in Russian).

6. Shankaran S., Pappas A., McDonald S. A., Vohr B. R., Hintz S. R., Yolton K. [et al.]. Childhood outcomes after hypothermia for neonatal encephalopathy. New England Journal of Medicine, 2012, vol. 366, no. 22, pp. 2085–2092. https://doi.org/10.1056/nejmoa1112066

7. Shankaran S., Laptook A. R., Tyson J. E., Ehrenkranz R. A., Bann C. M., Das A. [et al.]. Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. Journal of Pediatrics, 2012, vol. 160, no. 4, pp. 567–572.e3. https://doi.org/10.1016/j.jpeds.2011.09.018

8. van Handel M., Swaab H., de Vries L. S., Jongmans M. J. Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. European Journal of Pediatrics, 2007, vol. 166, no. 7, pp. 645–654. https://doi.org/10.1007/s00431-007-0437-8

9. Morozov S. G., Gnedenko B. B. Instructions for the use of a reagent kit for semi-quantitative determination of idiotypic and anti-idiotypic antibodies to neuroantigens in the blood serum (ELISA-NEURO-AT). Minsk, 2004. 10 p. (in Russian).

10. Kramer D. Mathematical processing of data in social sciences: modern methods. Moscow, Akademiya Publ., 2007. 288 p. (in Russian).

11. Rebrova O. Yu. Statistical analysis of medical data: STATISTICA. Moscow, MediaSfera Publ., 2006. 312 p. (in Russian).

12. Poletaev A. B. Clinical and laboratory immunology. Moscow, MIA Publ., 2007. 180 p. (in Russian).

13. Albagachieva D. I. Pro-apoptotic factors in the pathogenesis of hypoxic-ischemic lesions of the central nervous system in newborn infants. Abstract of Ph. D. diss. Moscow, 2010. 31 p. (in Russian).

14. Smirnov I. E., Ivanov V. A., Kucherenko A. G., Akoev Yu. S., Zainiddinova R. S., Rovenskaya Yu. V. Neuro-specifc biomarkers in the diagnosis of the effects of perinatal lesions of the nervous system in children of the frst year of life. Rossiiskii pediatricheskii zhurnal [Russian journal of pediatrics], 2011, no. 2, pp. 4–7 (in Russian).