Application of basophil activation and degranulation markers for diagnosis of pollen allergy
https://doi.org/10.29235/1814-6023-2018-15-4-405-413
Abstract
There are several basophil activation and degranulation markers for basophil activation test discovered in recent years. However, only CD63 and CD203c are actively used. The activation and degranulation markers (CD11b, CD13, CD63, CD69, CD107a, CD164, CD203c and CD300a) were characterized from the point of view of the possibility to use for BAT and their clinical efficiency. It has been shown that the degranulation marker CD107a and the activation marker CD11b have high sensitivity and specificity and can be used to diagnose hypersensitivity to pollen allergens.
About the Authors
I. U. Ramanava
Republican Research and Practical Center for Epidemiology and Microbiology, Minsk
Belarus
Researcher
Belarus
Researcher
A. Y. Hancharou
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, Minsk
Belarus
Ph. D. (Med.), Director
Belarus
Ph. D. (Med.), Director
N. I. Dudarava
10th City Clinical Hospital, Minsk
Belarus
Ph. D. (Med.), Head of the Department
Belarus
Ph. D. (Med.), Head of the Department
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Review
For citations:
Ramanava I.U., Hancharou A.Y., Dudarava N.I. Application of basophil activation and degranulation markers for diagnosis of pollen allergy. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(4):405-413. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-4-405-413
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