CARDIOPROTECTIVE EFFICIENCY OF REMOTE ISCHEMIC PRECONDITIONING DURING ISCHEMIA-REPERFUSION IN RATS WITH EXPERIMENTAL DYSLIPIDEMIA
https://doi.org/10.29235/1814-6023-2018-15-2-215-221
Abstract
The search for new effective methods of preventing or reducing ischemic myocardial injury and its mechanisms of realization is an actual problem of modern experimental and clinical medicine. The aim of the study was to determine the reproducibility of antiischemic and antiarrhythmic effects of the remote ischemic preconditioning myocardium of rats with dysrlipidemia (DLE). It was found that remote ischemic preconditioning is not effective in terms of necrosis zone size limits in the left ventricle during ischemia-reperfusion in rats with DLE. At the same time, after the reproduction of remote ischemic preconditioning in rats with DLE, a pronounced antiarrhythmic effect takes place, as evidenced the decrease in the duration of ischemic heart rhythm disturbances by 85 % (p < 0.05). The findings indicate the need for a differentiated approach to the appointment of remote ischemic preconditioning in patients with acute myocardial infarction. The existence of such a risk factor for cardiovascular diseases such as DLE can be a criterion for exclusion remote ischemic preconditioning as a way of reducing ischemic and reperfusion injury of the myocardium in patients with acute myocardial infarction.
About the Authors
F. I. Vismont
Belarusian State Medical University.
Belarus
Belarus
Frantishek I. Vismont – Corresponding Member, D. Sc. (Med.), Professor, Head of the Department.
83, Dzerzhinskiy Ave., 220116, Minsk.
S. N. Chepelev
Belarusian State Medical University.
Belarus
Belarus
Sergey N. Chepelev – Assistant.
83, Dzerzhinskiy Ave., 220116, Minsk.
A. N. Glebov
Belarusian State Medical University.
Belarus
Belarus
Andrey N. Glebov – Ph. D. (Med.), Assistant Professor.
83, Dzerzhinskiy Ave., 220116, Minsk.
A. F. Vismont
Belarusian State Medical University.
Belarus
Belarus
Arvid F. Vismont – Ph. D. (Med.), Senior researcher.
83, Dzerzhinskiy Ave., 220116, Minsk.
P. F. Jushkevich
Belarusian State Medical University.
Belarus
Belarus
Pavel F. Jushkevich – Ph. D. (Med.), Assistant.
83, Dzerzhinskiy Ave., 220116, Minsk.
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Review
For citations:
Vismont F.I., Chepelev S.N., Glebov A.N., Vismont A.F., Jushkevich P.F. CARDIOPROTECTIVE EFFICIENCY OF REMOTE ISCHEMIC PRECONDITIONING DURING ISCHEMIA-REPERFUSION IN RATS WITH EXPERIMENTAL DYSLIPIDEMIA. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(2):215-221. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-2-215-221
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