ANTHENATAL MYOCARDITISES OF CHILDREN

Abstract

Anthenatal myocarditises develop in the period of pre-natal development of fetus. The leading role in their genesis is played by somatic diseases of expectant mother, placenta permeability disorder, mother and fetus immunity reduction, fetus pre-natal hypoxia. Fibro-elastosis or elasto-fibrosis is a compulsory morphological substrate. This is associated with the specific feature of the fetus response to the action of an inflammatory agent to the 7th month of gestation. During the mentioned period, fetus tissues cannot exhibit a classical inflammation reaction. As a result, a diffuse thickening of endocardium formed by collagen or elastic tissue is seen in the majority of fetuses. Owing to this fact, the presence of fibro-elastosis or elasto-fibrosis is a marker of early anthenatal myocarditis. At late congentinal myocarditis, a normal inflammatory reaction occurs.

The article presents the modern concepts of congentinal myocarditises of children, as well as the considerations of ethiology and clinical implications of early and late anthenatal myocarditises of children. The basic approaches to the detection, differential diagnosis and treatment of disease depending on the period of fetus infection are described.