EFFECT OF ALCOHOL CONSUMPTION ON THE RISK OF METABOLIC SYNDROME
Abstract
The meta-analysis of prospective studies suggested that heavy alcohol consumption might be associated with an increased risk of metabolic syndrome while very light alcohol consumption seemed to be associated with a reduced risk of metabolic syndrome. Light-to-moderate alcohol consumption decreased the hypertension risk in women and increased the risk in men. Increased uptake of alcohol is related to a statistically significant but quantitatively small increase in the body weight of men. A dual relationship exists between alcohol consumption and diabetes mellitus. Light-to-moderate drinking may be beneficial while heavy drinking is detrimental.
About the Author
P. S. PRONKO
Institute of Biochemistry Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
References
1. Избыточная масса тела и ожирение: эффективность модификации образа жизни и контроля поступающих с пищей жиров / Л. И. Данилова [и др.] // Здравоохранение. – 2014. – № 12. – С. 50–53.
2. Global strategy to reduce the harmful use of alcohol. – Geneva: WHO, 2010. – 38 p.
3. Alcohol consumption, alcohol dependence and attributable burden of disease in Europe: potential gains from effective interventions for alcohol dependence / J. Rehm [et al.] // Center for Addiction and Mental Health. – 2012. – 144 p.
4. Global status report on alcohol and health 2014 / World Health Organization, 2014.
5. World Health Organization. Global status report on alcohol and health. – Geneva, Switzerland: WHO Press, 2011. – 286 p.
6. World Health Organization. The ICD-10 classification of mental and behavioral disorders: diagnostic criteria for research. – Geneva, Switzerland: World Health Organization, 1993.
7. Baik, I. Prospective study of alcohol consumption and metabolic syndrome / I. Baik, Ch. Shin // Am. J. Clin. Nutr. – 2008. – Vol. 87. – P. 1455–1463.
8. Alcohol consumption and the prevalence of metabolic syndrome: a meta-analysis of observational studies / A. Alkerwi [et al.] // Atherosclerosis. – 2009. – Vol. 204, N 2. – P. 624–635.
9. Alcohol consumption and risk of metabolic syndrome: a meta-analysis of prospective studies / K. Sun [et al.] // Clin. Nutrition. – 2013. – Vol. 33, N 4. – P. 596–602.
10. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and metaanalysis/ P. E. Ronksley [et al.] // B. M. J. – 2011. – Vol. 342. – doi: 10.1136/bmj.d671.
11. Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis / H. Han [et al.] // Gene. – 2013. – Vol. 526 (2). – P. 134–141.
12. Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies / S. E. Brien [et al.] // B. M. J. – 2011. – Vol. 342. – doi: 10.1136/bmj.d636.
13. Influence of pattern of drinking on cardiovascular disease and cardiovascular risk factors: a review / I. B. Puddey [et al.] // Addiction. – 1999. – Vol. 94. – P. 649–663.
14. Rehm, J. Average volume of alcohol consumption, patterns of drinking and risk of coronary heart disease: a review / J. Rehm, C. Sempos, M. Trevisan // J. Cardiovasc. Risk. – 2003. – Vol. 10. – P. 15–20.
15. Roerecke, M. Ischemic heart disease mortality and morbidity rates in former drinkers: a meta-analysis / M. Roerecke, J. Rehm // Am. J. Epidemiol. – 2011. – Vol. 173, N 3. – P. 245–258.
16. Alcohol consumption and the risk of hypertension in women and men / H. D. Sesso [et al.] // Hypertension. – 2008. – Vol. 51. – P. 1080–1087.
17. High-density lipoprotein subclasses are a potential intermediary between alcohol intake and reduced risk of cardiovascular disease: the Rancho Bernardo Study / N. D. Muth // Br. J. Nutr. – 2010. – Vol. 104, N 7. – P. 1034–1042.
18. Wakabayashi, I. Relationship between alcohol intake and lipid accumulation product in middle-aged men / I. Wakabayashi // Alcohol Alcohol. – 2013. – Vol. 48, N 5. – P. 535–542.
19. Klop, B. Alcohol and plasma triglycerides / B. Klop, A. T. do Rego, M. C. Cabezas // Curr. Opin. Lipidol. – 2013. – Vol. 24, N 4. – P. 321–326.
20. Metabolic and biochemical effects of low-to-moderate alcohol consumption / J. B. Whitfield [et al.] // Alcohol Clin. Exp. Res. – 2013. – Vol. 37, N 4. – P. 575–586.
21. Brinton, E. A. Effects of ethanol intake on lipoproteins / E. A. Brinton // Curr. atherosclerosis reports. – 2012. – Vol. 14, N 2. – P. 108–114.
22. Effects of moderate red wine consumption on liver fat and blood lipids: a prospective randomized study / S. Kechagias [et al.] // Ann. Med. – 2011. – Vol. 43, N 7. – P. 545–554.
23. A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients / J. P. Rifler [et al.] // Mol. Nutr. Food Res. – 2012. – Vol. 56, N 2. – P. 345–351.
24. Sozio, M. S. What advice should be given to patients with NAFLD about the consumption of alcohol? / M. S. Sozio, N. Chalasani, S. Liangpunsakul // Nat. Clin. Pract. Gastroenterol. Hepatol. – 2009. – Vol. 6. – P. 18–19.
25. Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications / L. Liu [et al.] // Endocrinol. Metab. Immune. Disord. Drug Targets. – 2008. – Vol. 8. – P. 89–98.
26. Causal Role of Alcohol Consumption in an Improved Lipid Profile: The Atherosclerosis Risk in Communities (ARIC) Study / N. Vu. Khanh [et al.] // PLoS One. – 2016. – Vol. 11, N 2.: e0148765. Publ. online 2016 Feb 5. doi: 10.1371/journal. pone.0148765.
27. Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study / D. A. Lawlor [et al.] // Eur. Heart. J. – 2013. – Vol. 34, N 32. – P. 2519–2528.
28. Cederbaum, A. I. Alcohol metabolism / A. I. Cederbaum // Clin. Liver Dis. – 2012. – Vol. 16, N 4. – P. 667–685.
29. Lands, W. E. M. A review of alcohol clearance in humans / W. E. M. Lands // Alcohol. – 1998. – Vol. 15, N 2. – P. 147–160.
30. Lieber, C. S. Ethanol metabolism, cirrhosis and alcoholism / C. S. Lieber // Clin. Chim. Acta. – 1997. – Vol. 257, N 1. – P. 59–84.
31. Ishii, H. The significance and means to limit alcohol consumption / H. Ishii // J. Jap. Med. Assoc. – 2007. – Vol. 136 (Special Issue 1). – P. S213–S216.
32. Sim, F. Alcoholic drinks contribute to obesity and should come with mandatory calorie counts / F. Sim // BMJ. – 2015. – Vol. 350:h2047.
33. Alcohol consumption and body weight / M. T. French [et al.] // Health Econ. – 2010. – Vol. 19, N 7. – P. 814–832.34. Leibowitz, S. F. Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides / S. F. Leibowitz // Physiol. Behav. – 2007. – Vol. 91, N 5. – P. 513–521.
34. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women / F. B. Hu [et al.] // N. Engl. J. Med. – 2001. – Vol. 345, N 11. – P. 790–797.
35. Moderate alcohol consumption lowers the risk of type 2 diabetes: A meta-analysis of prospective observational studies / L. L. Koppes [et al.] // Diabetes Care. – 2005. – Vol. 28, N 3. – P. 719–725.
36. Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial / M. J. Davies [et al.] // JAMA. – 2002. – Vol. 287, N 19. – P. 2559– 2562. 38. Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis / D. Baliunas [et al.] // Diabetes Care. – 2009. – Vol. 32. – P. 2123–2132.
37. The effect of alcohol intake on insulin sensitivity in men / R. R. Zilkens [et al.] // Diabetes Care. – 2003. – Vol. 26. – P. 608–612.
38. Effect of moderate alcoholic beverage consumption on insulin sensitivity in insulin resistant, nondiabetic individuals / S. H. Kim [et al.] // Metabolism. – 2009. – Vol. 58, N 3. – P. 387–392.
39. Alcoholic liver disease and its relationship with metabolic syndrome / H. Ishii [et al.] // JMAJ. – 2010. – Vol. 53, N 4. – P. 236–242.
40. Effects of body weight and alcohol consumption on insulin sensitivity / Q. X. Paulson [et al.] // Nutrition J. – 2010. – Vol. 10. – P. 9–14.
41. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action / C. Lindtner [et al.] // Sci. Transl. Med. – 2013. – Vol. 170: 170ra14.
42. Lieber, C. S. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis / C. S. Lieber // Alcohol. – 2004. – Vol. 34. – P. 9–19.
43. Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics / H. Iturriaga [et al.] // Am. J. Clin. Nutr. – 1988. – Vol. 47. – P. 235–238.
44. Ruhl, C. E. Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population / C. E. Ruhl, J. E. Everhart // Clin. Gastroenterol. Hepatol. – 2005. – Vol. 3. – P. 1260–1268.
Review
For citations:
PRONKO P.S. EFFECT OF ALCOHOL CONSUMPTION ON THE RISK OF METABOLIC SYNDROME. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2016;(3):117-125. (In Russ.)
Views: 655
Email this article 