DYNAMICS OF MORPHOLOGICAL CHANGES IN THE RAT CEREBELLUM AFTER CHRONIC PRENATAL ALCOHOL EXPOSURE

P. A. SUKHADOLSKI; D. N. PUKHAU; S. M. ZIMATKIN

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DYNAMICS OF MORPHOLOGICAL CHANGES IN THE RAT CEREBELLUM AFTER CHRONIC PRENATAL ALCOHOL EXPOSURE

P. A. SUKHADOLSKI, D. N. PUKHAU, S. M. ZIMATKIN

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Abstract

Prenatal exposure to ethanol leads to various structural abnormalities in the developing cerebellum, some of them remain for a long time. The most substantial changes, such as cortex layers thickening, reduction of Purkinje cell count and changes of the cell chromatophilia, take place during the period of differentiation of Purkinje cells and foliation of cerebellum – on the 20th day of postnatal life. To the age of 45 days the histological picture tends to normalize, though some parameters remain abnormal: the area of Purkinje cells decreases and the thickness of the cerebellar cortex remains increased.

Keywords

cerebellum, development, alcohol, fetal alcohol syndrome

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For citations:

SUKHADOLSKI P.A., PUKHAU D.N., ZIMATKIN S.M. DYNAMICS OF MORPHOLOGICAL CHANGES IN THE RAT CEREBELLUM AFTER CHRONIC PRENATAL ALCOHOL EXPOSURE. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2016;(3):86-92. (In Russ.)

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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)

Proceedings of the National Academy of Sciences of Belarus, Medical series

DYNAMICS OF MORPHOLOGICAL CHANGES IN THE RAT CEREBELLUM AFTER CHRONIC PRENATAL ALCOHOL EXPOSURE

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Proceedings of the National Academy of Sciences of Belarus, Medical series

DYNAMICS OF MORPHOLOGICAL CHANGES IN THE RAT CEREBELLUM AFTER CHRONIC PRENATAL ALCOHOL EXPOSURE

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

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