vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-325Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEДИНАМИКА МОРФОЛОГИЧЕСИХ НАРУШЕНИЙ В МОЗЖЕЧКЕ КРЫС ПОСЛЕ ХРОНИЧЕСКОЙ АНТЕНАТАЛЬНОЙ АЛКОГОЛИЗАЦИИDYNAMICS OF MORPHOLOGICAL CHANGES IN THE RAT CEREBELLUM AFTER CHRONIC PRENATAL ALCOHOL EXPOSUREСУХОДОЛЬСКИЙП. А.SUKHADOLSKIP. A.paul.sukhadolski@gmail.comПУХОВД. Н.PUKHAUD. N.ЗИМАТКИНС. М.ZIMATKINS. M.Гродненский государственный медицинский университетGrodno State Medical University201619112016038692Copyright © СУХОДОЛЬСКИЙ П.А., ПУХОВ Д.Н., ЗИМАТКИН С.М., 20162016СУХОДОЛЬСКИЙ П.А., ПУХОВ Д.Н., ЗИМАТКИН С.М.SUKHADOLSKI P.A., PUKHAU D.N., ZIMATKIN S.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/325

Антенатальная алкоголизация вызывает разнообразные структурные нарушения развития коры мозжечка, большинство из которых сохраняется на протяжении длительного времени. Наиболее выраженные изменения (увеличение толщины слоев коры мозжечка, уменьшение количества клеток Пуркинье, а также изменение их хроматофилии в сторону преобладания патологических форм клеток при снижении количества нормальных форм) наблюдаются в период поздней стадии дифференцировки и фолиации мозжечка – на 20-е сутки постнатального развития. К 45-м суткам постнатального развития морфологическая картина мозжечка отчасти нормализуется, при этом уменьшаются размеры перикарионов клеток Пуркинье и сохраняется увеличенная толщина коры.

Prenatal exposure to ethanol leads to various structural abnormalities in the developing cerebellum, some of them remain for a long time. The most substantial changes, such as cortex layers thickening, reduction of Purkinje cell count and changes of the cell chromatophilia, take place during the period of differentiation of Purkinje cells and foliation of cerebellum – on the 20th day of postnatal life. To the age of 45 days the histological picture tends to normalize, though some parameters remain abnormal: the area of Purkinje cells decreases and the thickness of the cerebellar cortex remains increased.

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