ТРАНСПЛАНТАЦИЯ АУТОЛОГИЧНЫХ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК ПАЦИЕНТАМ С РАССЕЯННЫМ СКЛЕРОЗОМ
Анатацыя
Рассеянный склероз (РС) – хроническое заболевание центральной нервной системы, сопровождающееся разнообразными неврологическими симптомами и в течение нескольких лет приводящее к инвалидизации. Лечение РС является одной из наиболее актуальных и сложных проблем практической медицины. Применение имеющихся на сегодняшний день препаратов позволяет лишь снизить частоту и тяжесть обострений, что для лечения хронических неврологических расстройств явно недостаточно. Трансплантация гемопоэтических клеток является одним из перспективных методов лечения РС. В обзоре представлен анализ результатов клинических исследований по применению трансплантации гемопоэтических стволовых клеток при лечении больных РС.
Аб аўтарах
О. ГичкунРасія
Е. Ярошенко
Расія
А. Шевченко
Расія
Спіс літаратуры
1. Frohman, E. M. Multiple sclerosis the plaque and its pathogenesis / E. M. Frohman, M. K. Racke, C. S. Raine // N. Engl. J. Med. – 2006. – N 354. – P. 942–955.
2. Рассеянный склероз / под ред. Е. И. Гусева, И.А. Завалишина, А.Н. Бойко. – М.: Реал Тайм, 2011. – 528 с.
3. Dendrou, C. A. Immunopathology of multiple sclerosis / C. A. Dendrou, L. Fugger, M. A. Friese // Nat. Rev. Immunol. – 2015. – Vol. 15, N 9. – Р. 545–558. – doi: 10.1038/nri3871. Epub. 2015 Aug. 7.
4. Riedhammer, C. Antigen presentation, autoantigens, and immune regulation in Multiple sclerosis and other autoimmune diseases / C. Riedhammer, R. Weissert // Front Immunol. – 2015. – Vol. 17, N 6. – Р. 322. – doi: 10.3389/fim-mu.2015.00322. eCollection 2015.
5. Atkins, H. L. Hematopoietic stem cell therapy for multiple sclerosis: top 10 lessons learned / H. L. Atkins, M. S. Freedman // Neurotherapeutics. – 2013. – Vol. 10, N 1. – Р. 68–76. – doi: 10.1007/s13311-012-0162-5.
6. Ribatti, D. The fundamental contribution of Robert A. Good to the discovery of the crucial role of thymus in mammalian immunity / D. Ribatti // Immunology. – 2006. – Vol. 119, N 3. – Р. 291–295.
7. Complications of allogeneic hematopoietic stem cell transplantation / K. Arnaout [et al.] // Cancer Invest. – 2014. – Vol. 32, N 7. – P. 349–362. – doi: 10.3109/07357907.2014.919301. Epub. 2014 June 5.
8. Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation / D. M. Karussis [et al.] // J. Clin. Invest. – 1993. – N 92. – Р. 765–772.
9. Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation / J. A. Snowden [et al.] // Bone Marrow Transplant. – 2012. – N 47. – Р. 770–790.
10. Transplantation for autoimmune diseases in north and south america: a report of the Center for International Blood and Marrow Transplant Research / M. C. Pasquini [et al.] // Biol. Blood Marrow Transplant. – 2012. – N 18. – Р. 1471–1478.
11. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study / A. Fassas [et al.] // Bone Marrow Transplant. – 1997. – Vol. 20, N 8.– P. 631–638. – doi:10.1038/sj. bmt.1700944.
12. Autologous stem cell transplantation in progressive multiple sclerosis – an interim analysis of efficacy / A. Fassas [et al.] // J. Clin. Immunol. – 2000. – Vol. 20, N 1. – P. 24–30.
13. Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study / A. Fassas [et al.] // J. Neurol. – 2002. – Vol. 249, N 8. – P. 1088–1097. – doi:10.1007/s00415-002-08007.
14. High dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis / T. Kozak [et al.] // Bone Marrow Transplant. – 2000. – Vol. 25, N 5. – P. 525-531. – doi:10.1038/sj.bmt.1702180.
15. Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring / H. Openshaw [et al.] // Biol. Blood Marrow Transplant. – 2000. – Vol. 6, N 5A. – P. 563–575.
16. Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores / R. K. Burt [et al.] // Blood. – 2003. – Vol. 102, N 7. – P. 2373–2378. – doi:10.1182/blood-2003-03-0877.
17. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis / R. A. Nash [et al.] // Blood. – 2003. – Vol. 102, N 7. – P. 2364–2372. – doi:10.1182/blood-2002-12-3908.
18. Clinical and MRI outcome after autologous hematopoietic stem cell transplantation iMS / A. Saiz [et al.] // Neurology. – 2004. – Vol. 62, N 2. – P. 282–284.
19. Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life / R. Saccardi [et al.] // Blood. – 2005. – Vol. 105, N 6. – P. 2601–2607. – doi:10.1182/ blood-2004-08-3205.
20. Autologous stem cell transplantation for progressive multiple sclerosis: update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database / R. Saccardi [et al.] // Mult. Scler. – 2006. – Vol. 12, N 6. – P. 814–823.
21. Intense T-cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis / J. P. Samijn [et al.] // J. Neurol. Neurosurg. Psychiatry. – 2006. – Vol. 77, N 1. – P. 46–50. – doi:10.1136/jnnp.2005.063883.
22. Clinical outcomes after autologous haematopoietic stem cell transplantation in patients with progressive multiple sclerosis / J. Xu [et al.] // Chin. Med. J. (Engl.). – 2006. – Vol. 119, N 22. – P. 1851–1855.
23. High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation as a treatment option in multiple sclerosis / Y. L. Shevchenko [et al.] // Exp. Hematol. – 2008. – Vol. 36, N 8. – P. 922–928. – doi:10.1016/j.ex-phem.2008.03.001.
24. Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing remitting multiple sclerosis: a phase I/II study / R. K. Burt [et al.] // Lancet Neurol. – 2009. – Vol. 8, N 3. – P. 244–253. – doi:10.1016/S1474-4422(09)70017-1.
25. Fagius, J. Early highly aggressive MS successfully treated by hematopoietic stem cell transplantation / J. Fagius, J. G. Lundgren // Oberg. Mult. Scler. – 2009. – Vol. 15, N 2. – P. 229–237. – doi:10.1177/1352458508096875.
26. High-dose immunoablation with autologous haematopoietic stem cell transplantation in aggressive multiple scle- rosis: a single center 10-year experience / E. Krasulova [et al.] // Mult. Scler. – 2010. – Vol. 16, N 6. – P. 685–693. – doi:10.1177/1352458510364538.
27. Brazilian experience with two conditioning regimens in patients with multiple sclerosis: BEAM/ horse ATG and CY/ rabbit ATG / N. Hamerschlak [et al.] // Bone Marrow Transplant. – 2010. – Vol. 45, N 2. – P. 239–48. – doi:10.1038/bmt.2009.127.
28. Long-term results of stem cell transplantation for MS: a single-center experience / A. Fassas [et al.] // Neurology. – 2011. – Vol. 76, N 12. – P. 1066–1070. – doi:10.1212/WNL.0b013e318211c537. Outcome of HSCT in MS patients after a median follow-up of 11 years.
29. Autologous hematopoietic stem cell transplantation with reduced-intensity conditioning in multiple sclerosis / Y. L. Shevchenko [et al.] // Exp. Hematol. – 2012. – Vol. 40, N 11. – P. 892–898. – doi:10.1016/j.exphem.2012.07.003.
30. Autologous hematopoietic cell transplantation following high-dose immunosuppressive therapy for advanced multiple sclerosis: long-term results / J. D. Bowen [et al.] // Bone Marrow Transplant. – 2012. – Vol. 47, N 7. – P. 946–951. – doi:10.1038/bmt.2011.208.
31. Autologous haematopoietic stem cell transplantation with an intermediaten intensity conditioning regimen in multiple sclerosis: the Italian multi-center experience / G. L. Mancardi [et al.] // Mult. Scler. – 2012. – Vol. 18, N 6. – P. 835–842. – doi:10.1177/1352458511429320. Italian study of autologous HSCT in MS with BEAM/ATG conditioning regimen.
32. Long-term efficacy оf autologous haematopoietic stem cell transplantation in multiple sclerosis at a single institution in China / B. Chen [et al.] // Neurol. Sci. – 2012. – Vol. 33, N 4. – P. 881–886. – doi:10.1007/s100720110859-y.
33. Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience / J. Burman [et al.] // J. Neurol. Neurosurg. Psychiatry. – 2014. – doi:10.1136/jnnp-2013-307207.
34. Havrdova, E. Aggressive multiple sclerosis – is there a role for stem cell transplantation? / E. Havrdova // J. Neurol. – 2005. – N 252 (Suppl. 3). – P. III34–III37.
35. Italian GITMO-NEURO Intergroup on Autologous Stem Cell Transplantation. The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study / L. Roccatagliata [et al.] // Mult. Scler. – 2007. – N 13. – P. 1068–1070.
36. Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients / P. A. Muraro [et al.] // J. Exp. Med. – 2005. – N 201. – P. 805–816.
37. Autologous hematopoietic stem cell transplantation in multiple sclerosis: a phase II trial / G. L. Mancardi [et al.] // Neurology. – 2015. – Vol. 84, N 10. – P. 981–988. – doi: 10.1212/WNL.0000000000001329. Epub. 2015 Feb. 11.
##reviewer.review.form##
Для цытавання:
Гичкун О.Е., Ярошенко Е.Б., Шевченко А.О. ТРАНСПЛАНТАЦИЯ АУТОЛОГИЧНЫХ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК ПАЦИЕНТАМ С РАССЕЯННЫМ СКЛЕРОЗОМ. Известия Национальной академии наук Беларуси. Серия медицинских наук. 2016;(2):110-117.
For citation:
Gichkun O.E., Yaroshenko E.B., Shevchenko A.O. HAEMATOPOIETIC STEM CELL TRANSPLANTATION TO PATIENTS WITH MULTIPLE SCLEROSIS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2016;(2):110-117. (In Russ.)