ПРИМЕНЕНИЕ ЭМБРИОНАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК ЧЕЛОВЕКА: МЕДИЦИНСКИЕ И БИОЭТИЧЕСКИЕ АСПЕКТЫ
Аннотация
Обоснован терапевтический потенциал эмбриональных стволовых клеток человека для их использования в регенеративной медицине.Проанализированы философско-методологические и биоэтические проблемы клинического применения эмбриональных стволовых клеток человека и предложены возможные пути их решения.
Ключевые слова
Об авторах
Е. В. Кувырков
Республиканский научно-практический центр трансфузиологии и медицинских биотехнологий
Беларусь
Беларусь
П. А. Водопьянов
Белорусский государственный технологический университет
Беларусь
Беларусь
С. М. Космачева
Республиканский научно-практический центр трансфузиологии и медицинских биотехнологий
Беларусь
Беларусь
Список литературы
1. Embryonic stem cells lines derived from human blastocysts / J. A. Thomson [et al.] // Science. – 1998. – Vol. 282. – P. 1145–1147.
2. Takahashi, K. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors / K. Takahashi, S. Yamanaka // Cell. – 2006. – Vol. 126, N 4. – P. 663–676.
3. Okita, K. Generation of germline-competent induced pluripotent stem cells / K. Okita, T. Ichisaka, S. Yamanaka // Nature. – 2007. – Vol. 448, N 7151. – P. 313–317.
4. Gurdon, J. B. Nuclear transfer to eggs and oocytes / J. B. Gurdon, I. Wilmut // Cold Spring Harbor Perspectives Biology. – 2011. – Vol. 3, N 6. – Doi: 10.1101/cshperspect.a002659.
5. Induction of pluripotent stem cells from adult human fibroblasts by defined factors / K. Takahashi [et al.] // Cell. – 2007. – Vol. 131, N 5. – P. 861–872.
6. Induced pluripotent stem cell lines derived from human somatic cells / J. Yu [et al.] // Science. – 2007. – Vol. 318, N 5858. – P. 1917–1920.
7. Knoepfler, P. S. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine / P. S. Knoepfler // Stem Cells. – 2009. – Vol. 27, N 5. – P. 1050–1056.
8. Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection / I. Gutierrez-Aranda [et al.] // Stem Cells. – 2009. – Vol. 28, N 9. – P. 1568–1570.
9. Salem, H. K. Mesenchymal stromal cells: current understanding and clinical status / H. K. Salem, C. Thiemermann // Stem Сells. – 2010. – Vol. 28. – P. 585–596.
10. Edwards, R. G. Causes of early embryonic loss in human pregnancy / R. G. Edwards // Hum. Reprod. – 1986. – Vol. 1, N 3. – P. 185–198.
11. Greber, B. Fibroblast growth factor 2 modulates transforming growth factor β signaling in mouse embryonic fibro-blasts and human ESCs (hESCs) to support hESC self-renewal / B. Greber, H. Lehrach, J. Adjaye // Stem Cells. – 2007. – Vol. 25. – P. 455–464.
12. A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cell / L. Eiselleova [et al.] // Stem Cells. – 2009. – Vol. 27, N 8. – P. 1847–1857.
13. Greber, B. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal / B. Greber, H. Lehrach, J. Adjaye // BMC Dev. Biol. – 2007. – Vol. 7. – Doi:10.1186/1471-213X-7-46.
14. LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells / L. Daheron [et al.] // Stem Cells. – 2004. – Vol. 22. – P. 770–778.
15. Odorico, J. S. Multilineage differentiation from human embryonic stem cells line / J. S. Odorico, D. S. Kaufman, J. A. Tomson // Stem Cells. – 2001. – Vol. 19. – P. 193–204.
16. Gerrard, L. Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling / L. Gerrard, L. Rodgers, W. Cui // Stem Cells. – 2005. – Vol. 23. – P. 1234–1241.
17. Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells / M. Richards [et al.] // Nat. Biotechnol. – 2002. – Vol. 20. – P. 933–936.
18. Human feeder layers for human embryonic stem cells / M. Amit [et al.] // Biol. Reprod. – 2003. – Vol. 68. – P. 2150–2156.
19. Human-serum matrix supports undifferentiated growth of human embryonic stem cells / P. Stojkovic [et al.] // Stem Cells. – 2005. – Vol. 23. – P. 895–902.
20. Feeder layer- and serum-free culture of human embryonic stem cells / M. Amit [et al.] // Biol. Reprod. – 2004. – Vol. 70. – P. 837–845.
21. Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells / T. Fujikawa [et al.] // Am. J. Pathol. – 2005. – Vol. 166, N 6. – P. 1781–1791.
22. Erceg, S. Human embryonic stem cell differentiation toward regional specific neural precursors / S. Erceg, M. Ronaghi, M. Stojković // Stem Cells. – 2009. – Vol. 27, N 1. – P. 78–87.
23. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells / C. Xu [et al.] // Circ. Res. – 2002. – Vol. 91. – P. 501–508.
24. Generation of insulin-producing islet-like clusters from human embryonic stem cells / J. Jiang [et al.] // Stem Cells. – 2007. – Vol. 25, N 8. – P. 1940–1953.
25. Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines / N. B. Woods [et al.] // Stem Cells. – 2011. – Vol. 29, N 7. – P. 1158–1164.
26. Agarwal, S. Efficient differentiation of functional hepatocytes from human embryonic stem cells / S. Agarwal, K. L. Hol-ton, R. Lanza // Stem Cells. – 2008. – Vol. 26, N 5. – P. 1117–1127.
27. Биология стволовых клеток и клеточные технологии / под ред. М. А. Пальцева. – М.: Изд-во «Медицина»; Изд-во «Шико», 2009. – Т. 1. – 272 с.
28. Skorb, E. V. Surface nanoarchitecture for bio-applications: self-regulating intelligent interfaces / E. V. Skorb, D. V. And-reeva // Adv. Funct. Mater. – 2013. – Vol. 23. – P. 4483–4506.
29. Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells / W. Chen [et al.] // ACS Nano. – 2012. – Vol. 6. – P. 4094–4103.
30. Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells / E. Kingham [et al.] // Small. – 2013. – Vol. 9. – P. 2140–2151.
31. Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine / E. Kingham [et al.] // ACS Nano. – 2013. – Vol. 7. – P. 1867–1881.
32. Changes in embryonic stem cell colony morphology and early differentiation markers driven by colloidal crystal topographical cues / L. Ji [et al.] // Eur. Cell Mater. – 2012. – Vol. 23. – P. 135–146.
33. Regulation of stem cells fate by nanomaterial substrate / O. Mashinchian [et al.] // Nanomedicine. – 2015. – Vol. 10, N 5. – P. 829–847.
34. Skorb, E. V. Dynamic interfaces for responsive encapsulation systems / E. V. Skorb, H. Moehwald // Adv. Mater. – 2013. – Vol. 36. – P. 5029–5043.
35. McCall Smith, A. The use of embryonic stem cells in therapeutic research / A. McCall Smith, M. Revel // Report of the IBC on the ethical aspects of human embryonic stem cell research. – Paris: UNESCO, 2001.
36. The European convention on human rights and biomedicine [Electronic resource]. – 1997. – Mode of access: http: // europatientrights.eu/biomedicine_convention/biomedicine_convention_text.html. – Date of access: on August 26, 2015.
37. Declaration of defense of cloning and the integrity of scientific research / P. Admiraal [et al.] // Free Inquiry. – 1997. – Vol. 17, N 3. – P. 11–12.
38. The human embryonic stem cell debate: science, ethics and public policy / ed. by S. Holland, K. Lebacqz, L. Zoloth. – Cambridge: MIT PRESS, 2001. – P. 257.
39. The pew forum on religion and public life, religious groups official positions on stem cell research [Electronic resource]. – 2008. – Mode of access: http://pewforum.org/docs/?DocID=319. – Date of access: August 26, 2015.
40. McLaren, A. IVF: regulation or prohibition? / A. McLaren // Nature. – 1989. – Vol. 342, N 6249. – P. 469–470.
41. Edwards, R. G. New ethical implications of human embryology / R. G. Edwards // Hum. Reprod. – 1986. – Vol. 1, N 4. – P. 277–278.
42. Vogel, G. Harnessing the power of stem cells / G. Vogel // Science. – 1999. – Vol. 283. – P. 1432–1434.
43. Universal declaration on the human genome and human rights [Electronic resource]. – 1997. – Mode of access: http:// portal.unesco.org/en/ev.php-URL_ID=13177&URL_DO=DO_TOPIC&URL_SECTION=201.html. – Date of acce ss: August 26, 2015.
Рецензия
Для цитирования:
Кувырков Е.В., Водопьянов П.А., Космачева С.М. ПРИМЕНЕНИЕ ЭМБРИОНАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК ЧЕЛОВЕКА: МЕДИЦИНСКИЕ И БИОЭТИЧЕСКИЕ АСПЕКТЫ. Известия Национальной академии наук Беларуси. Серия медицинских наук. 2016;(2):102-109.
For citation:
Kuvyrkov E.V., Vodopyanov P.A., Kosmacheva S.M. APPLICATION OF HUMAN EMBRYONIC STEM CELLS: MEDICAL AND BIOETHICAL ASPECTS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2016;(2):102-109. (In Russ.)
Просмотров: 645
Послать статью по эл. почте 