Pharmacokinetics of colistin in children with chemotherapy-induced neutropenia
Abstract
The spread of nosocomial multidrug-resistant strains of P. aeruginosa, A. baumannii and K. pneumoniae brought back the need of colistin use. However, the data concerning pharmacokinetics of colistin is lacking, precluding from optimal dosing of the drug, especially in critically ill patients.The pharmacokinetics of colistin and colistimethate sodium in children with chemotherapy-induced neutropenia was studied. The serum concentration of colistin was determined by high performance liquid chromatography (HPLC) and mass spectrometry. The concentration of colistin after intravenous administration of colistimethate sodium was determined in 21 children (13 patients with sepsis, 8 children in the control group) with chemotherapy-induced neutropenia.The significant variability of pharmacokinetic parameters of colistin in patients with sepsis and in the control group was revealed. HPLC and mass spectrometry can be used for therapeutic drug monitoring and optimizing of the dosing regime.
About the Authors
В. Захаревич
Республиканский научно-практический центр детской онкологии, гематологии и иммунологии
Belarus
Belarus
П. Шабуня
Институт биоорганической химии НАН Беларуси
Belarus
Belarus
С. Фатыхова
Институт биоорганической химии НАН Беларуси
Belarus
Belarus
П. Курман
Институт биоорганической химии НАН Беларуси
Belarus
Belarus
В. Дмитриев
Республиканский научно-практический центр детской онкологии, гематологии и иммунологии
Belarus
Belarus
О. Алейникова
Республиканский научно-практический центр детской онкологии, гематологии и иммунологии
Belarus
Belarus
References
1. Giamarellou H., Antoniadou А. // Med. Clin. N. Am. 2001. Vol. 85. P. 19-42.
2. Evans M. E., Feola D. J., Rapp R. P. // Ann. Pharmacother. 1999. Vol. 33. P. 960-967.
3. Barnett M., Bushby S. R., Wilkinson S. // Br. J. Pharmacol. 1964. Vol. 23. P. 552-574.
4. Schwartz B. S., Warren M. R., Barkley F. A. et al. // Antibiotics Ann. 1959-1960. Vol. 7. Р. 41-60.
5. Li J., Turnidge J., Milne R., Nation R. L. et al. // Antimicrob. Agents Chemother. 2001. Vol. 45. P. 781-785.
6. Jian Li, Robert W., Milnel R. еt al. // Antimicrob. Agents Chemother. 2002. Vol. 46, N 10. P. 3304-3307.
7. Jian Li, Kingsley Coulthard, Robert Milne1 et al. // J. of Antimicrob. Chemother. 2003. Vol. 52. P. 987-992.
8. He H., Li J. C., Nation R. L. et al. // J. Antimicrob. Chemother. 2013. Vol. 68, N 10. P. 2311-2317.
9. Lee J., Han S., Jeon S. et al. // Antimicrob. Agents Chemother. 2013. Vol. 57, N 5. P. 2141-2146.
10. Imberti R., Cusato M., Accetta G. et al. // Antimicrob. Agents Chemother. 2012. Vol. 56, N 8. P. 4416-4421.
11. Ly N. S., Yang J., Bulitta J. B., Tsuji B. T. // Antimicrob. Agents Chemother. 2012. Vol. 56, N 6. P. 3453-3456.
12. Cooper T. W., Pass S. E., Brouse S. D., Hall Ii R. G. // Ann. Pharmacother. 2011. Vol. 45, N 2. P. 229-240.
13. Bergen P. J., Li J., Rayner C. R. et al. // Antimicrob. Agents Chemother. 2006. Vol. 50. P. 1953-1958.
14. Gobin P., Lemaitre F., Marchand S. et al. // Antimicrob. Agents Chemother. 2010. Vol. 54, N 5. P. 1941-1948.
15. Dotsikas Y., Markopoulou C. K., Koundourellis J. E. et al. // J. Sep. Sci. 2011. Vol. 34. P. 37-45.
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, , , , , Pharmacokinetics of colistin in children with chemotherapy-induced neutropenia. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(1):37-41. (In Russ.)
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