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Atherosclerosis in patients with rheumatoid arthritis: the role of oxidized low-density lipoproteins

Abstract

The relationship between the content of oxidized low-density lipoproteins (LDL), the inflammation activity, and subclinical atherosclerosis was studied by the multispiral computed tomography with the screening of coronary calcium and by the ultrasonography of carotid arteries in patients with rheumatoid arthritis (RA). A greater prevalence of atherosclerotic lesions of coronary and carotid arteries was observed in patients with RA treated with methotrexate compared with indicators of age, sex and cardiovascular risk factors in persons without RA predicted by index DAS 28, the level of high-sensitivity C-reactive protein, age and the presence of hypertension. The RA activity can influence the atherosclerosis development through the peroxide modification of LDL.

About the Authors

T. A. Kurak
Belarusian State Medical University
Belarus


N. P. Mitkovskaya
Belarusian State Medical University
Belarus


L. L. Avdey
Minsk Consulting and Diagnostic Centre
Belarus


T. V. Ilyina
Minsk Consulting and Diagnostic Centre
Belarus


E. I. Shkrebneva
9th Clinical Hospital
Belarus


Zh. N. Kot
9th Clinical Hospital
Belarus


E. B. Petrova
Belarusian State Medical University
Belarus


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Review

For citations:


Kurak T.A., Mitkovskaya N.P., Avdey L.L., Ilyina T.V., Shkrebneva E.I., Kot Zh.N., Petrova E.B. Atherosclerosis in patients with rheumatoid arthritis: the role of oxidized low-density lipoproteins. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2014;(4):4-8. (In Russ.)

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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)