Functional properties of CD+CD25+FoxP3+ T-lymphocytes and their importance for graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation
https://doi.org/10.29235/1814-6023-2026-23-1-77-88
Abstract
CD4+CD25+FoxP3+ regulatory cells (Tregs) are a special lineage of cells central in the maintenance of immune homeostasis. In this review, we have analyzed the available data on CD4+CD25+FoxP3+ Tregs. We have summarized the basic information about the various subpopulations of Tregs, the mechanisms of their differentiation, their immunosuppressive properties and the possibility of clinical use in graft-versus-host disease. Now a significant knowledge base has been accumulated about Tregs and clinical trials of their use in patients with graft-versus-host disease have begun.
About the Authors
H. A. Zhernasechanka
Republican Research Center for Pediatric Oncology, Hematology and Immunology
Belarus
Belarus
Hanna A. Zhernasechanka – Ph. D. (Biol.), Leading Researcher
43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region
Ju. V. Savich
Republican Research Center for Pediatric Oncology, Hematology and Immunology
Belarus
Belarus
Juliya V. Savich – Researcher
43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region
T. V. Shman
Republican Research Center for Pediatric Oncology, Hematology and Immunology
Belarus
Belarus
Tatsiana V. Shman – Ph. D. (Biol.), Leading Researcher
43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region
Ya. I. Isaikina
Republican Research Center for Pediatric Oncology, Hematology and Immunology
Belarus
Belarus
Yanina I. Isaikina – Ph. D. (Biol.), Associate Professor, Head of the Laboratory
43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region
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Review
For citations:
Zhernasechanka H.A., Savich J.V., Shman T.V., Isaikina Ya.I. Functional properties of CD+CD25+FoxP3+ T-lymphocytes and their importance for graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2026;23(1):77-88. (In Russ.) https://doi.org/10.29235/1814-6023-2026-23-1-77-88
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