vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2026-23-1-77-88vestim-1077Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEФункциональные свойства CD+CD25+FoxP3+ Т-лимфоцитов и их значение для реакции «трансплантат против хозяина» у пациентов после аллогенной трансплантации гемопоэтических стволовых клетокFunctional properties of CD+CD25+FoxP3+ T-lymphocytes and their importance for graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantationhttps://orcid.org/0009-0006-9593-7067ЖерносеченкоА. А.ZhernasechankaH. A.

Жерносеченко Анна Александровна – канд. биол. наук, вед. науч. сотрудник

ул. Фрунзенская, 43, 223053, д. Боровляны, Минский р-н

Hanna A. Zhernasechanka – Ph. D. (Biol.), Leading Researcher 

43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region

https://orcid.org/0009-0002-4713-4578СавичЮ. В.SavichJu. V.

Савич Юлия Валерьевна – науч. сотрудник 

ул. Фрунзенская, 43, 223053, д. Боровляны, Минский р-н

Juliya V. Savich – Researcher 

43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region

savich.juliya@yandex.ruhttps://orcid.org/0000-0001-8669-8005ШманТ. B.ShmanT. V.

Шман Татьяна Викторовна – канд. биол. наук, вед. науч. сотрудник 

ул. Фрунзенская, 43, 223053, д. Боровляны, Минский р-н

Tatsiana V. Shman – Ph. D. (Biol.), Leading Researcher 

43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region

shman@oncology.byhttps://orcid.org/0000-0001-5196-8554ИсайкинаЯ. И.IsaikinaYa. I.

Исайкина Янина Ивановна – канд. биол. наук, доцент, заведующий лабораторией 

ул. Фрунзенская, 43, 223053, д. Боровляны, Минский р-н

Yanina I. Isaikina – Ph. D. (Biol.), Associate Professor, Head of the Laboratory 

43, Frunzenskaya Str., 223053, Borovlyany v., Minsk region

yaninai@mail.ruРеспубликанский научно-практический центр детской онкологии, гематологии и иммунологииRepublican Research Center for Pediatric Oncology, Hematology and Immunology2026030320262317788Copyright © Жерносеченко А.А., Савич Ю.В., Шман Т.B., Исайкина Я.И., 20262026Жерносеченко А.А., Савич Ю.В., Шман Т.B., Исайкина Я.И.Zhernasechanka H.A., Savich J.V., Shman T.V., Isaikina Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/1077

Регуляторные Т-лимфоциты CD4+CD25+FoxP3+ (Treg) представляют собой особую субпопуляцию Т-хелперов, играющих центральную роль в поддержании иммунного гомеостаза. В работе мы проанализировали имеющиеся данные о CD4+CD25+FoxP3+ Тreg. Нами суммирована основная информация о различных субпопуляциях Тreg, механизмах их дифференцировки, иммуносупрессивных свойствах и возможности клинического применения при терапии реакции «трансплантат против хозяина». В настоящее время, благодаря значительному исследовательскому интересу, накоплена значительная база знаний о Тreg и начаты клинические испытания их использования у пациентов с реакцией «трансплантат против хозяина».

CD4+CD25+FoxP3+ regulatory cells (Tregs) are a special lineage of cells central in the maintenance of immune homeostasis. In this review, we have analyzed the available data on CD4+CD25+FoxP3+ Tregs. We have summarized the basic information about the various subpopulations of Tregs, the mechanisms of their differentiation, their immunosuppressive properties and the possibility of clinical use in graft-versus-host disease. Now a significant knowledge base has been accumulated about Tregs and clinical trials of their use in patients with graft-versus-host disease have begun.

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The authors declare that there are no conflicts of interest present.