Changes in biochemical blood indicators in primary liver cancer associated with viruses
https://doi.org/10.29235/1814-6023-2024-21-3-241-250
Abstract
Currently, about million new cases of liver cancer (LC) are being registered annually in the world, causing death in 85 % of patients.
The purpose of the study is to establish the features of changes in biochemical blood parameters in RP against the background of persistence of DNA/RNA viruses.
Patients (n = 247) with morphologically established liver cancer, hepatitis and healthy individuals were examined. The subject of research was the biochemical and molecular biological parameters of DNA/RNA viruses. It was established that the nature of biochemical changes and disorders in patients with liver cancer indicates a simultaneous violation of most physiological functions of parenchymal organs, in which syndromes of cytolysis, cholestasis, immune and autoimmune disorders are simultaneously formed, the main role in which belongs to infectious (DNA/RNA viruses) and oncological processes. The most important biochemical markers in liver cancer are enzymes (AST, ALT, ALP, LDH, alpha-amylase), bilirubin, creatinine, albumin, triglycerides, GGTP, microelements (biogenic – magnesium, phosphorus, calcium). Among the viruses detected during liver cancer, the leading role belongs to viruses verified in tumor tissue, the presence of which causes persistent biochemical changes: VEB and HHV6.
About the Authors
A. E. Kuzniatsou
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Russian Federation
Russian Federation
Aleh E. Kuzniatsou – Ph. D. (Biol.), Associate Professor, Director
7, An. Tyzenhauz Sq., 230023, Grodno
V. M. Tsyrkunov
Grodno State Medical University
Belarus
Belarus
Vladimir M. Tsyrkunov – D. Sc. (Med.), Professor
80, Gorky Str., 230009, Grodno
M. V. Ershova
Grodno University Clinic
Belarus
Belarus
Marina V. Ershova – Head of the Laboratory
52, Lenin Komsomol Boulevard, Grodn
I. L. Parai
Grodno University Clinic
Belarus
Belarus
Irina L. Parai – doctor of clinical laboratory diagnostics
52, Lenin Komsomol Boulevard, Grodno
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Review
For citations:
Kuzniatsou A.E., Tsyrkunov V.M., Ershova M.V., Parai I.L. Changes in biochemical blood indicators in primary liver cancer associated with viruses. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2024;21(3):241-250. (In Russ.) https://doi.org/10.29235/1814-6023-2024-21-3-241-250
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