Frequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan population
https://doi.org/10.29235/1814-6023-2023-20-4-347-352
Abstract
This study investigated a range of gene polymorphisms encoding IL-1, IL-6, IL-10, and TNF-α ‒308 in 100 healthy unrelated Kazakhs using real-time PCR. The findings were compared with published data on other populations. The distribution of genotypes was consistent with the Hardy-Weinberg equilibrium. However, the frequency of cytokine genotypes observed in the Kazakh population showed similarities and differences compared to neighboring ethnic groups. The most noticeable differences compared with Iranians, Turks, Russians, and Chinese were observed in the distribution of IL-1, IL-6, and IL-10 genotypes. The frequency of the TNF-α ‒308 genotype differed only with the Iranian population. Thus, our study showed a link between cytokine gene polymorphism and ethnicity. These results may be of clinical relevance in understanding the prevalence of diseases in Kazakhstan.
Keywords
allele frequencies,
cytokines,
gene polymorphism,
population study,
Kazakh population,
Hardy-Weinberg equilibrium
Supporting agencies: The study was supported by a grant from the Marat Ospanov West Kazakhstan Medical University.
About the Authors
T. A. Jarkenov
West Kazakhstan Marat Ospanov Medical University
Kazakhstan
Kazakhstan
Timur А. Jarkenov ‒ D. Sc. (Med.), Professor, West Kazakhstan Marat Ospanov Medical University.
68, Maresyev Str., 030019, Aktobe
S. Т. Zairova
Talgat Bigeldinov Military Institute of the Air Defence Forces
Kazakhstan
Kazakhstan
Saule Т. Zairova ‒ Ph. D. (Med.), Head of the psychological support service, Military Institute of Air Defense named after T. J. Begeldinov.
39, Aliya Moldagulova Ave., 030012, Aktobe
S. K. Sakhanova
West Kazakhstan Marat Ospanov Medical University
Kazakhstan
Kazakhstan
Svetlana К. Sakhanova ‒ D. Sc. (Med.), Professor, Head of the scientific and practical center, West Kazakhstan Marat Ospanov Medical University.
68, Maresyev Str., 030019, Aktobe
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Review
For citations:
Jarkenov T.A., Zairova S.Т., Sakhanova S.K. Frequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan population. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2023;20(4):347-352. https://doi.org/10.29235/1814-6023-2023-20-4-347-352
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