vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2023-20-4-347-352vestim-941Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEРаспределение частот полиморфизмов четырех генов цитокинов в здоровой популяции Западного КазахстанаFrequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan populationhttps://orcid.org/0000-0003-4579-6412ДжаркеновТ. А.JarkenovT. A.

Джаркенов Тимур Агатаевич ‒ доктор медицинских наук, профессор.

ул. Маресьева, 68, 030019, Актобе

Timur А. Jarkenov ‒ D. Sc. (Med.), Professor, West Kazakhstan Marat Ospanov Medical University.

68, Maresyev Str., 030019, Aktobe

timurjarkenov@zkmu.kzhttps://orcid.org/0000-0003-1896-2307ЗаироваС. Т.ZairovaS. Т.

Заирова Сауле Тимуровна – кандидат медицинских наук, начальник службы психологического обеспечения.

пр. Алии Молдагуловой, 39, 030012, Актобе

Saule Т. Zairova ‒ Ph. D. (Med.), Head of the psychological support service, Military Institute of Air Defense named after T. J. Begeldinov.

39, Aliya Moldagulova Ave., 030012, Aktobe

zairova.saule@gmail.comhttps://orcid.org/0000-0001-9786-6326СахановаС. К.SakhanovaS. K.

Саханова Светлана Калиуллаевна – доктор медицинских наук, профессор, руководитель научно-практического центра.

ул. Маресьева, 68, 030019, Актобе

Svetlana К. Sakhanova ‒ D. Sc. (Med.), Professor, Head of the scientific and practical center, West Kazakhstan Marat Ospanov Medical University.

68, Maresyev Str., 030019, Aktobe

Sakhanova68@zkmu.kzЗападно-Казахстанский медицинский университет имени Марата ОспановаWest Kazakhstan Marat Ospanov Medical UniversityВоенный институт Сил воздушной обороны имени дважды Героя Советского Союза Т.Я. БегельдиноваTalgat Bigeldinov Military Institute of the Air Defence Forces202302122023204347352Copyright © Джаркенов Т.А., Заирова С.Т., Саханова С.К., 20232023Джаркенов Т.А., Заирова С.Т., Саханова С.К.Jarkenov T.A., Zairova S.Т., Sakhanova S.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/941

Изучен ряд полиморфизмов генов, кодирующих IL-1, IL-6 и IL-10 и TNF-α ‒308, у 100 здоровых неродственных казахов с использованием ПЦР в реальном времени. Полученные результаты сравнивали с опубликованными данными по другим популяциям. Распределение генотипов соответствовало равновесию Харди-Вайнберга. Однако наблюдаемая частота генотипов цитокинов в казахской популяции показала сходство и различия по сравнению с соседними этническими группами. Наиболее заметные различия по сравнению с иранцами, турками, русскими и китайцами наблюдались в распределении генотипов IL-1, IL-6 и IL-10. Частота генотипа TNF-α ‒308 различалась только в иранской популяции. Таким образом, наше исследование показало связь между полиморфизмом генов цитокинов и этнической принадлежностью. Полученные нами результаты могут быть клинически значимы для понимания распространенности заболеваний в Казахстане.

This study  investigated  a  range  of  gene  polymorphisms  encoding  IL-1,  IL-6,  IL-10, and TNF-α ‒308 in 100 healthy unrelated Kazakhs using real-time PCR. The findings were compared with published data on other populations. The distribution of genotypes was consistent with the Hardy-Weinberg equilibrium. However, the frequency of cytokine genotypes observed in the Kazakh population showed similarities and differences compared to neighboring ethnic groups. The most noticeable differences compared with Iranians, Turks, Russians, and Chinese were observed in the distribution of IL-1, IL-6, and IL-10 genotypes. The frequency of the TNF-α ‒308 genotype differed only with the Iranian population. Thus, our study showed a link between cytokine gene polymorphism and ethnicity. These results may be of clinical relevance in understanding the prevalence of diseases in Kazakhstan.

частоты аллелейцитокиныполиморфизм геновпопуляционное исследованиеказахская популяцияравновесие Харди-Вайнбергаallele frequenciescytokinesgene polymorphismpopulation studyKazakh populationHardy-Weinberg equilibriumИсследование поддержано грантом Западно-Казахстанского медицинского университета имени Марата Оспанова.The study was supported by a grant from the Marat Ospanov West Kazakhstan Medical University.ReferencesDinarello C. A. Historical insights into cytokines. European Journal of Immunology, 2007, vol. 37, suppl. 1, pp. 34−45. https://doi.org/10.1002/eji.200737772Dinarello C. A. Historical insights into cytokines. European Journal of Immunology, 2007, vol. 37, suppl. 1, pp. 34−45. https://doi.org/10.1002/eji.200737772Bhushan S., Perumal N. B. Disease associated cytokine SNPs database: an annotation and dissemination model. Cytokine, 2012, vol. 57, no. 1, pp. 107−112. https://doi.org/10.1016/j.cyto.2011.10.009Bhushan S., Perumal N. B. 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The authors declare that there are no conflicts of interest present.