Распределение частот полиморфизмов четырех генов цитокинов в здоровой популяции Западного Казахстана

Изучен ряд полиморфизмов генов, кодирующих IL-1, IL-6 и IL-10 и TNF-α ‒308, у 100 здоровых неродственных казахов с использованием ПЦР в реальном времени. Полученные результаты сравнивали с опубликованными данными по другим популяциям. Распределение генотипов соответствовало равновесию Харди-Вайнберга. Однако наблюдаемая частота генотипов цитокинов в казахской популяции показала сходство и различия по сравнению с соседними этническими группами. Наиболее заметные различия по сравнению с иранцами, турками, русскими и китайцами наблюдались в распределении генотипов IL-1, IL-6 и IL-10. Частота генотипа TNF-α ‒308 различалась только в иранской популяции. Таким образом, наше исследование показало связь между полиморфизмом генов цитокинов и этнической принадлежностью. Полученные нами результаты могут быть клинически значимы для понимания распространенности заболеваний в Казахстане.

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