Frequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan population

T. A. Jarkenov; S. Т. Zairova; S. K. Sakhanova

doi:10.29235/1814-6023-2023-20-4-347-352

Frequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan population

T. A. Jarkenov, S. Т. Zairova, S. K. Sakhanova

https://doi.org/10.29235/1814-6023-2023-20-4-347-352

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Abstract

This study investigated a range of gene polymorphisms encoding IL-1, IL-6, IL-10, and TNF-α ‒308 in 100 healthy unrelated Kazakhs using real-time PCR. The findings were compared with published data on other populations. The distribution of genotypes was consistent with the Hardy-Weinberg equilibrium. However, the frequency of cytokine genotypes observed in the Kazakh population showed similarities and differences compared to neighboring ethnic groups. The most noticeable differences compared with Iranians, Turks, Russians, and Chinese were observed in the distribution of IL-1, IL-6, and IL-10 genotypes. The frequency of the TNF-α ‒308 genotype differed only with the Iranian population. Thus, our study showed a link between cytokine gene polymorphism and ethnicity. These results may be of clinical relevance in understanding the prevalence of diseases in Kazakhstan.

Keywords

allele frequencies, cytokines, gene polymorphism, population study, Kazakh population, Hardy-Weinberg equilibrium

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For citations:

Jarkenov T.A., Zairova S.Т., Sakhanova S.K. Frequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan population. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2023;20(4):347-352. https://doi.org/10.29235/1814-6023-2023-20-4-347-352

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)

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Proceedings of the National Academy of Sciences of Belarus, Medical series

Frequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan population

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Proceedings of the National Academy of Sciences of Belarus, Medical series

Frequency distribution of four cytokine gene polymorphisms in healthy Western Kazakhstan population

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About the Authors

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