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Известия Национальной академии наук Беларуси. Серия медицинских наук

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Современные представления об остеогенном потенциале мезенхимальных стволовых клеток и создании биоинженерных конструкций для репарации костной ткани

https://doi.org/10.29235/1814-6023-2020-17-4-500-508

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Аннотация

В статье суммируются современные представления об остеогенном потенциале мезенхимальных стволовых клеток (МСК) и опыте применения различных носителей для восстановления костной ткани. Понимание реализации программы остеогенеза в МСК сможет существенно расширить возможности применения этих клеток в составе биоинженерных конструкций. На сегодняшний день накоплен большой объем экспериментальных данных по изучению механизма остеогенной дифференцировки МСК, индукторов трансформации МСК в предшественники остеогенеза и созданию эквивалентов костной ткани биоинженерным путем с применением различных носителей. Особое внимание уделяется разработке материалов носителей и их проектированию, методам получения конструкций и взаимодействиям между скэффолдом и клетками, так как это имеет большое значение для дальнейшего функционирования биоинженерной ткани.

Об авторе

А. А. Жерносеченко
Республиканский научно-практический центр детской онкологии, гематологии и иммунологии
Россия

Жерносеченко Анна Александровна – научный сотрудник

ул. Фрунзенская, 43, 223053, Минский р-н, д. Боровляны



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Для цитирования:


Жерносеченко А.А. Современные представления об остеогенном потенциале мезенхимальных стволовых клеток и создании биоинженерных конструкций для репарации костной ткани. Известия Национальной академии наук Беларуси. Серия медицинских наук. 2020;17(4):500-508. https://doi.org/10.29235/1814-6023-2020-17-4-500-508

For citation:


Zhernasechanka H.A. Modern concepts of the osteogenic potential of mesenchymal stem cells and the creation of bioengineering structures for bone tissue repair. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2020;17(4):500-508. (In Russ.) https://doi.org/10.29235/1814-6023-2020-17-4-500-508

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ISSN 1814-6023 (Print)
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