Доступ открыт Открытый доступ  Доступ закрыт Только для подписчиков

Роль рецепторов, активирующих пролиферацию пероксисом, в контроле алкогольной зависимости и лечении сопутствующих заболеваний печени


https://doi.org/10.29235/1814-6023-2019-16-2-244-256

Полный текст:


Аннотация

Настоящий обзор посвящен систематизации разрозненных данных о биологической роли рецепторов, активирующих пролиферацию пероксисом (PPARs), и изучению возможности использования агонистов PPARs в лечении пациентов с алкогольной зависимостью и сопутствующими заболеваниями печени. Рассмотрены наиболее важные работы последних лет, раскрывающие терапевтический потенциал агонистов PPARs в качестве средств для лечения пациентов с алкогольной зависимостью.


Об авторах

И. Н. Семененя
Институт биохимии биологически активных соединений НАН Беларуси
Беларусь

Семененя Игорь Николаевич – д-р мед. наук, профессор, директор

Бульвар Ленинского комсомола, 50, 230030, г. Гродно



А. Г. Шляхтун
Институт биохимии биологически активных соединений НАН Беларуси
Беларусь

Шляхтун Алексей Генрихович – заведующий лабораторией

Бульвар Ленинского комсомола, 50, 230030, г. Гродно



Е. Ф. Радута
Институт биохимии биологически активных соединений НАН Беларуси
Беларусь

Радута Елена Францевна – ст. науч. сотрудник

Бульвар Ленинского комсомола, 50, 230030, г. Гродно



Список литературы

1. Miller, P. M. Medical treatment of alcohol dependence: a systematic review / P. M. Miller, S. W. Book, S. H. Stewart // Int. J. Psychiatry Med. – 2011. – Vol. 42, N 3. – P. 227–266. https://doi.org/10.2190/PM.42.3.b

2. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors / C. Dreyer [et al.] // Cell. – 1992. – Vol. 68, N 5. – P. 879–887. https://doi.org/10.1016/0092-8674(92)90031-7

3. Issemann, I. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators / I. Issemann, S. Green // Nature. – 1990. – Vol. 347, N 6294. – P. 645–650. https://doi.org/10.1038/347645a0

4. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors / S. A. Kliewer [et al.] // Proc. Natl. Acad. Sci. – 1994. – Vol. 91, N 15. – P. 7355–7359. https://doi.org/10.1073/pnas.91.15.7355

5. Grygiel-Górniak, B. Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications – a review / B. Grygiel-Górniak // Nutr. J. – 2014. – Vol. 13. – Art. 17. https://doi.org/10.1186/1475-2891-13-17

6. Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammation / J. Becker [et al.] // Pulm. Pharmacol. Ther. – 2008. – Vol. 21, N 2. – P. 324–330. https://doi.org/10.1016/j.pupt.2007.08.001

7. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms / E. Mueller [et al.] // J. Biol. Chem. – 2002. – Vol. 277, N 44. – P. 41925–41930. https://doi.org/10.1074/jbc.M206950200

8. Brunmeir, R. Functional regulation of PPARs through post-translational modifcations / R. Brunmeir, F. Xu // Int. J. Mol. Sci. – 2018. – Vol. 19, N 6. – Art. 1738. https://doi.org/10.3390/ijms19061738

9. Rochette-Egly, C. Nuclear receptors: integration of multiple signalling pathways through phosphorylation / C. Rochette-Egly // Cell Signal. – 2003. – Vol. 15, N 4. – P. 355–366. https://doi.org/10.1016/S0898-6568(02)00115-8

10. Zoete, V. Peroxisome proliferator-activated receptor structures: ligand specifcity, molecular switch and interactions with regulators / V. Zoete, A. Grosdidier, O. Michielin // Biochim. Biophys. Acta – Mol. Cell Biol. Lipids. – 2007. – Vol. 1771, N 8. – P. 915–925. https://doi.org/10.1016/j.bbalip.2007.01.007

11. Sonoda, J. Nuclear receptors: decoding metabolic disease / J. Sonoda, L. Pei, R. M. Evans // FEBS Lett. – 2008. – Vol. 582, N 1. – P. 2–9. https://doi.org/10.1016/j.febslet.2007.11.016

12. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors / H. E. Xu [et al.] // Mol. Cell. – 1999. – Vol. 3, N 3. – P. 397–403. https://doi.org/10.1016/S1097-2765(00)80467-0

13. Fatty acids, eicosanoids, and hypolipidemic agents identifed as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay / G. Krey [et al.] // Mol. Endocrinol. – 1997. – Vol. 11, N 6. – P. 779–791. https://doi.org/10.1210/mend.11.6.0007

14. Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1 alpha in human skeletal muscle, but not lipid regulatory genes / M. J. Watt [et al.] // J. Mol. Endocrinol. – 2004. – Vol. 33, N 2. – P. 533–544. https://doi.org/10.1677/jme.1.01499

15. Siersbaek, R. PPARgamma in adipocyte differentiation and metabolism – novel insights from genome-wide studies / R. Siersbaek, R. Nielsen, S. Mandrup // FEBS Lett. – 2010. – Vol. 584, N 15. – P. 3242–3249. https://doi.org/10.1016/j.febslet.2010.06.010

16. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPARalpha, -beta, and -gamma in the adult rat / O. Braissant [et al.] // Endocrinology. – 1996. – Vol. 137, N 1. – P. 354–366. https://doi.org/10.1210/endo.137.1.8536636.

17. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis / P. Lefebvre [et al.] // J. Clin. Invest. – 2006. – Vol. 116, N 3. – P. 571–580. https://doi.org/10.1172/JCI27989

18. Mechanism of action of fbrates on lipid and lipoprotein metabolism / B. Staels [et al.] // Circulation. – 1998. – Vol. 98, N 19. – P. 2088–2093. https://doi.org/10.1161/01.cir.98.19.2088

19. The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism / S. Kersten [et al.] // FASEB J. – 2001. – Vol. 15, N 11. – P. 1971–1978. https://doi.org/10.1096/fj.01-0147com

20. PPAR alpha regulation of the immune response and autoimmune encephalomyelitis / Y. Yang [et al.] // PPAR Res. – 2008. – Vol. 2008. – Art. ID 546753. https://doi.org/10.1155/2008/546753

21. Cannabinoids and PPARalpha signaling / Y. Sun [et al.] // Biochem. Soc. Trans. – 2006. – Vol. 34, N 6. – P. 1095–1097. https://doi.org/10.1042/BST0341095

22. Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion / N. R. Pandey [et al.] // Biochemistry. – 2008. – Vol. 47, N 6. – P. 1579–1587. https://doi.org/10.1021/bi702148f

23. The organization, promoter analysis, and expression of the human PPARgamma gene / L. Fajas [et al.] // J. Biol. Chem. – 1997. – Vol. 272, N 30. – P. 18779–18789. https://doi.org/10.1074/jbc.272.30.18779

24. PPARγ overexpression regulates cholesterol metabolism in human L02 hepatocytes / T. Han [et al.] // J. Pharmacol. Sci. – 2019. – Vol. 139, N 1. – P. 1–8. https://doi.org/10.1016/j.jphs.2018.09.013

25. Wang, S. PPARγ signaling and emerging opportunities for improved therapeutics / S. Wang, E. J. Dougherty, R. L. Danner // Pharmacol. Res. – 2016. – Vol. 111. – P. 76–85. https://doi.org/10.1016/j.phrs.2016.02.028

26. PPARgamma in the control of brown adipocyte differentiation / J. Nedergaard [et al.] // Biochim. Biophys. Acta – Mol. Cell Biol. Lipids. – 2005. – Vol. 1740, N 2. – P. 293–304. https://doi.org/10.1016/j.bbadis.2005.02.003

27. Positive relationship between dietary fat, ethanol intake, triglycerides, and hypothalamic peptides: counteraction by lipid-lowering drugs / J. R. Barson [et al.] // Alcohol. – 2009. – Vol. 43, N 6. – P. 433–441. https://doi.org/10.1016/j.alcohol.2009.07.003

28. Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking / S. Stopponi [et al.] // Biol. Psychiatry. – 2011. – Vol. 69, N 7. – P. 642–649. https://doi.org/10.1016/j.biopsych.2010.12.010

29. Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats / S. Stopponi [et al.] // Alcoholism: Clin. Exp. Res. – 2013. – Vol. 37, N 8. – P. 1351–1360. https://doi.org/10.1111/acer.12091

30. Different immune cells mediate mechanical pain hypersensitivity in male and female mice / R. E. Sorge [et al.] // Nat. Neurosci. – 2015. – Vol. 18, N 8. – P. 1081–1083. https://doi.org/10.1038/nn.4053

31. Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans / Y. A. Blednov [et al.] // Alcoholism: Clin. Exp. Res. – 2015. – Vol. 39, N 1. – P. 136–145. https://doi.org/10.1111/acer.12610

32. PPAR agonists: I. Role of receptor subunits in alcohol consumption in male and female mice / Y. A. Blednov [et al.] // Alcoholism: Clin. Exp. Res. – 2016. – Vol. 40, N 3. – P. 553–562. https://doi.org/10.1111/acer.12976

33. PPAR agonists: II. Fenofbrate and tesaglitazar alter behaviors related to voluntary alcohol consumption / Y. A. Blednov [et al.] // Alcoholism: Clin. Exp. Res. – 2016. – Vol. 40, N 3. – P. 563–571. https://doi.org/10.1111/acer.12972

34. Fenofbrate – a lipid-lowering drug – reduces voluntary alcohol drinking in rats / E. Karahanian [et al.] // Alcohol. – 2014. – Vol. 48, N 7. – P. 665–670. https://doi.org/10.1016/j.alcohol.2014.08.004

35. Влияние активаторов и ингибиторов каталазы на показатели фармакокинетики этанола и активность ферментов метаболизма этанола и ацетальдегида печени и мозга крыс / Л. Р. Бардина [и др.] // Биомед. химия. – 2010. – Т. 56, № 4. – С. 499–505.

36. PPAR agonists regulate brain gene expression: Relationship to their effects on ethanol consumption / L. B. Ferguson [et al.] // Neuropharmacology. – 2014. – Vol. 86. – P. 397–407. https://doi.org/10.1016/j.neuropharm.2014.06.024

37. Новые фармакологические подходы в терапии алкогольной зависимости: агонисты PPAR-рецепторов / А. Г. Шляхтун [и др.] // Современные проблемы биохимии и молекулярной биологии : сб. науч. ст., Гродно, 17–18 мая 2018 г. / НАН Беларуси, Ин-т биохимии биол. активных соединений НАН Беларуси ; под общ. ред. И. Н. Семенени, А. Г. Мойсеенка. – Минск, 2018. – С. 730–735.

38. Kelley, K. W. Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders / K. W. Kelley, R. Dantzer // Brain Behav. Immun. – 2011. – Vol. 25, Suppl. 1. – P. S13–S20. https://doi.org/10.1016/j.bbi.2010.12.013

39. Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation / C. Blanquart [et al.] // J. Steroid. Biochem. Mol. Biol. – 2003. – Vol. 85, N 2–5. – P. 267–273. https://doi.org/10.1016/S0960-0760(03)00214-0

40. Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels / S. Aleshin [et al.] // Mol. Pharmacol. – 2009. – Vol. 76, N 2. – P. 414–424. https://doi.org/10.1124/mol.109.056010

41. Nan, Y.-M. Peroxisome proliferator-activated receptor α, a potential therapeutic target for alcoholic liver disease / Y.-M. Nan, R.-Q. Wang, N. Fu // World J Gastroenterol. – 2014. – Vol. 20, N 25. – P. 8055–8060. https://doi.org/10.3748/wjg.v20.i25.8055

42. Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice / L. Kong [et al.] // Lipids Health. Dis. – 2011. – Vol. 10. – Art. 246. https://doi.org/10.1186/1476-511X-10-246

43. Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking / C. Wu [et al.] // Hepatology. – 2011. – Vol. 54, N 6. – P. 1966–1974. https://doi.org/10.1002/hep.24645

44. Hepatic peroxisome proliferator-activated receptor gamma signaling contributes to alcohol-induced hepatic steatosis and inflammation in mice / W. Zhang [et al.] // Alcohol Clin. Exp. Res. – 2016. – Vol. 40, N 5. – P. 988–999. https://doi.org/10.1111/acer.13049

45. The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats / S. Liu [et al.] // Eur. J. Pharmacol. – 2011. – Vol. 650, N 1. – P. 384–389. https://doi.org/10.1016/j.ejphar.2010.09.082

46. Zhang, F. Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fbrogenesis / F. Zhang, Y. Lu, S. Zheng // Cell. Signal. – 2012. – Vol. 24, N 3. – P. 596–605. https://doi.org/10.1016/j.cellsig.2011.11.008

47. PPARδ agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair / M. Pang [et al.] // J. Hepatol. – 2009. – Vol. 50, N 6. – P. 1192–1201. https://doi.org/10.1016/j.jhep.2009.01.021

48. Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy / N. K. H. Khoo [et al.] // Redox Biol. – 2013. – Vol. 1, N 1. – P. 70–79. https://doi.org/10.1016/j.redox.2012.12.006

49. Fenofbrate decreases radiation sensitivity via peroxisome proliferator-activated receptor α-mediated superoxide dismutase induction in HeLa cells / X. Liu [et al.] // Radiat. Oncol. J. – 2012. – Vol. 30, N 2. – P. 88–95. https://doi.org/10.3857/roj.2012.30.2.88


Дополнительные файлы

Для цитирования: Семененя И.Н., Шляхтун А.Г., Радута Е.Ф. Роль рецепторов, активирующих пролиферацию пероксисом, в контроле алкогольной зависимости и лечении сопутствующих заболеваний печени. Известия Национальной академии наук Беларуси. Серия медицинских наук. 2019;16(2):244-256. https://doi.org/10.29235/1814-6023-2019-16-2-244-256

For citation: Semenenya I.N., Shlyahtun A.H., Raduta H.F. Role of peroxisome proliferator-activated receptors in the control of alcohol dependence and concomitant liver pathology. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(2):244-256. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-2-244-256

Просмотров: 51

Обратные ссылки

  • Обратные ссылки не определены.


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)