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Proceedings of the National Academy of Sciences of Belarus, Medical series

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Evaluation of in vitro immunomodulatory properties of biologically active substances and drugs

https://doi.org/10.29235/1814-6023-2019-16-2-234-243

Abstract

A new combined method for screening of immunomodulatory properties of drugs was developed, including: expression of CD80, HLA-DR, CD32, CD205 and CD197, interleukin-12 production and apoptosis by DCs; production of reactive oxygen species and evaluation of phagocytosis by neutrophils; expression of CD69 and production of tumor necrosis factor-α by Jurkat-tat cells; and CD80 and HLA-DR expression, viability and apoptosis using the Daudi cell line.

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Duzh A.V., Hancharou A.Y. Evaluation of in vitro immunomodulatory properties of biologically active substances and drugs. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(2):234-243. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-2-234-243

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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)