Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen

I. P. Sutsko; A. G. Shlyahtun; O. V. Titko; N. V. Yankevich; P. G. Telegin; A. V. Kolodko; I. V. Zverinsky

doi:10.29235/1814-6023-2019-16-1-56-64

Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen

I. P. Sutsko, A. G. Shlyahtun, O. V. Titko, N. V. Yankevich, P. G. Telegin, A. V. Kolodko, I. V. Zverinsky

https://doi.org/10.29235/1814-6023-2019-16-1-56-64

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Abstract

The hepatoprotective effect of the self-emulsifying composition with berberine was studied in the model of toxic liver damage in rats with acetaminophen and its hepatoprotective properties were analyzed in comparison with the use of berberine in free form. The course introduction of self-emulsifying composition with berberine before intoxication of rats with acetaminophen to a greater extent inhibits the development of cytolysis of hepatocytes, and also promotes the enhancement of the glutathione unit of the antioxidant system, increasing the content of total and free sulfhydryl groups, compared with the introduction of free berberine in animals.

Keywords

berberine, self-emulsifying system, microemulsions, acetaminophen, hepatotoxicity

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For citations:

Sutsko I.P., Shlyahtun A.G., Titko O.V., Yankevich N.V., Telegin P.G., Kolodko A.V., Zverinsky I.V. Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(1):56-64. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-1-56-64

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)

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Proceedings of the National Academy of Sciences of Belarus, Medical series

Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen

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