Infectious status of children after renal transplantation and experience of etiotropic treatment of viral complications
https://doi.org/10.29235/1814-6023-2019-16-1-13-22
Abstract
The article presents the results of viral infections monitoring in children at different times after renal transplantation and experience of their use in treatment of post-transplant complications. This study presents the results of virological investigation of relevant agents of viral infections (CMV, EBV, HSV 1, 2 tons, HHV 6, HHV 7, VZV, ADV, BKV and JCV). The frequency of identifying the viral infections in blood in the early postoperative period (the frst 3 months after transplantation) was 20.0 %, in the late postoperative period – 8.0 %, in the case of graft dysfunction – 21.4 %. According to the results of PCR tests of urine, BK and / or JC viruses were identifed in 40.0 % of recipients in the early postoperative period and in 47.1 % of recipients in the late postoperative period. The dominant pathogens were polyomaviruses, BKV (22.9 %) prevailed in the early postoperative period, and JCV (36.8 %) in the late postoperative period. There are the examples of treatment of acute transplant rejection combined with HHV 6 viremia and graft dysfunction combined with a long-term persistence of BKV infection. The use of vanganciclovir in the frst case and the replacement mycophenolate mofetil (MMF) by azathioprine in the second one allowed stabilizing the function of the transplanted organ.
About the Authors
T. V. Amvrosieva
Republican Scientifc and Practical Center of Epidemiology and Microbiology
Belarus
Belarus
Tamara V. Amvrosieva – D. Sc. (Med.), Professor, Head of the Laboratory
23, Filimonov Str., 220114, Minsk
Z. F. Bohush
Republican Scientifc and Practical Center of Epidemiology and Microbiology
Belarus
Belarus
Zoja F. Bohush – Researcher
23, Filimonov Str., 220114, Minsk
E. P. Kishkurno
Belarusian Medical Academy of Postgraduate Education
Belarus
Belarus
Elena P. Kishkurno – Ph. D. (Med.), Assistant Professor
3/3, P. Browka Str., 220013, Minsk
S. V. Baiko
Belarusian State Medical University
Belarus
Belarus
Sergey V. Baiko – Ph. D. (Med.), Assistant Professor
83, Dzerzhinski Ave., 220116, Minsk
A. S. Arinovich
Republican Scientifc and Practical Center of Epidemiology and Microbiology
Belarus
Belarus
Alexandra S. Arinovich – Junior researcher
23, Filimonov Str., 220114, Minsk
N. V. Paklonskaya
Republican Scientifc and Practical Center of Epidemiology and Microbiology
Belarus
Belarus
Natalia V. Paklonskaya – Ph. D. (Biol.), Leading researcher
23, Filimonov Str., 220114, Minsk
A. V. Sukalo
Presidium of the National Academy of Sciences of Belarus
Belarus
Belarus
Alexandr V. Sukalo – Academician, D. Sc. (Med.), Professor, Head of the Department
66, Nezavisimosti Ave., 220072, Minsk
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Review
For citations:
Amvrosieva T.V., Bohush Z.F., Kishkurno E.P., Baiko S.V., Arinovich A.S., Paklonskaya N.V., Sukalo A.V. Infectious status of children after renal transplantation and experience of etiotropic treatment of viral complications. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(1):13-22. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-1-13-22
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