Role of stellate cells in the morphogenesis of chronic pancreatitis
https://doi.org/10.29235/1814-6023-2018-15-4-455-464
Abstract
This review presents an analysis of the literature on the role of pancreatic stellate cells (PSCs) in the pathogenesis of fibrosis, a predominant histological feature of chronic alcoholic pancreatitis. It is shown that ethanol and toxic products of its metabolism can affect PSCs directly and indirectly, facilitating their transformation from a quiescent to an activated state. During the pathological process, PSCs interact with parenchymal and immune cells of the pancreas through cytokines and growth factors. In activated PSCs, the proliferative and migratory activity, as well as the synthesis of extracellular matrix (ECM) proteins increases. A continuous activation of PSCs during the disease promotes the maintenance of inflammation, the deposition of excessive amounts of ECM proteins and the development of pancreatic fibrosis.
About the Author
L. A. Mozhejko
Grodno State Medical University, Grodno
Belarus
Ph. D. (Med.), Assistant Professor
Belarus
Ph. D. (Med.), Assistant Professor
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Review
For citations:
Mozhejko L.A. Role of stellate cells in the morphogenesis of chronic pancreatitis. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(4):455-464. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-4-455-464
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