MORPHOMETRIC PARAMETERS OF LIVER REGENERATION IN CASE OF PARTIAL HEPATECTOMY AND MESENCHYMAL STEM CELLS TRANSPLANTATION IN EXPERIMENT
Abstract
Morphological figures of liver regeneration on the experimental model of organ resection of healthy animals and rats treated with retrorsine, as well as the influence of the transplantation of mesenchymal stem cells on the regenerative processes in liver are investigated.
It was revealed that the mechanism of regeneration of healthy liver after resection mainly involved mature hepatocytes with strengthening their mitotic activity and with increasing the nuclear apparatus. During the liver resection on the background of the retrorsin-induced injury the regeneration processes was greatly weakened. Intraportal transplantation of mesenchymal stem cells in liver resection contributed to improving the regenerative processes both in the healthy liver and in the case of the retrorsin-induced injury of the liver.
It was revealed that the mechanism of regeneration of healthy liver after resection mainly involved mature hepatocytes with strengthening their mitotic activity and with increasing the nuclear apparatus. During the liver resection on the background of the retrorsin-induced injury the regeneration processes was greatly weakened. Intraportal transplantation of mesenchymal stem cells in liver resection contributed to improving the regenerative processes both in the healthy liver and in the case of the retrorsin-induced injury of the liver.
About the Authors
A. G. Skuratov
Gomel State Medical University
Russian Federation
Ph. D. (Med.), Asso-ciate Professor, Department of surgical diseases N 1.
Russian Federation
Ph. D. (Med.), Asso-ciate Professor, Department of surgical diseases N 1.
A. N. Lyzikov
Gomel State Medical University
Russian Federation
D. Sc. (Med.), Professor, Rector
Russian Federation
D. Sc. (Med.), Professor, Rector
D. A. Zinovkin
Gomel State Medical University
Russian Federation
pathologist, laboratory of cell technologies
Russian Federation
pathologist, laboratory of cell technologies
I. A. Cheshik
Institute of Radiobiology of the National Academy of Sciences of Belarus
Russian Federation
Ph. D. (Med.), Director
Russian Federation
Ph. D. (Med.), Director
D. R. Petrenyov
Institute of Radiobiology of the National Academy of Sciences of Belarus
Russian Federation
Senior Researcher
Russian Federation
Senior Researcher
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Review
For citations:
Skuratov A.G., Lyzikov A.N., Zinovkin D.A., Cheshik I.A., Petrenyov D.R. MORPHOMETRIC PARAMETERS OF LIVER REGENERATION IN CASE OF PARTIAL HEPATECTOMY AND MESENCHYMAL STEM CELLS TRANSPLANTATION IN EXPERIMENT. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2016;(4):57-65. (In Russ.)
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