Intensity of metabolic and hormonal processes after dopamine receptors activation in the obesity modeling
Abstract
In order to study whether dopamine agonists have influence on metabolic and hormonal changes in the diet-induced obesity, a set of tests was performed in young male rats (n = 48), divided into groups according to a food caloric value and a pharmacological agent influencing dopamine receptors (DR). A weight gain and a decrease in the heat production intensity of animals take place when a daily energy intake is increased regardless of the DR functional state. Serum leptin concentration and leptin resistance levels decrease in rats with a prolonged administration of DR2 agonist (Bromocriptin®). A regulated growth of the DR2 functional activity in diet-induced obese animals leads to leptin secretion weakening and leptin resistance decrease, which is directed to decrease appetite.
About the Authors
L. S. Viazova
Белорусский государственный медицинский университет
Belarus
Belarus
A. V. Solntseva
Белорусский государственный медицинский университет
Belarus
Belarus
A. V. Sukalo
Белорусский государственный медицинский университет
Belarus
Belarus
E. O. Volokitin
Институт физиологии НАН Беларуси
Belarus
Belarus
J. P. Stukach
Институт физиологии НАН Беларуси
Belarus
Belarus
V. A. Kulchitski
Институт физиологии НАН Беларуси
Belarus
Belarus
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Review
For citations:
Viazova L.S., Solntseva A.V., Sukalo A.V., Volokitin E.O., Stukach J.P., Kulchitski V.A. Intensity of metabolic and hormonal processes after dopamine receptors activation in the obesity modeling. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(2):10-18. (In Russ.)
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