Importance of the apoptosis of smooth muscle cells and macrophages of the coronary artery wall in the pathogenesis of atherosclerosis
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Abstract
In the investigation of the coronary arteries of the dead from the coronary heart disease, it is found that in atherosclerosis there occur both pathological activation and inhibition of the apoptosis of major cells of the coronary artery with atherosclerotic lesions. The apoptosis of smooth muscle cells and macrophages of coronary artery atherosclerotic lesions is realized by the caspase-dependent mechanism. The apoptosis of endothelial cells can occur with the participation of caspases and by the caspase-independent mechanism. The presence of moderate cytoplasmic expression of cytochrome c in all stages atherogenesis stages confirms the mitochondrial activation of the caspase cascade.
Keywords
апоптотический индекс,
апоптозиндуцирующий фактор,
гладкомышечные клетки,
макрофаги,
ишемическая болезнь сердца,
каспазы,
цитохром,
эндотелиальные клетки,
Apoptotic index,
apoptosis-inducing factor,
smooth muscle cells,
macrophages,
coronary heart disease,
caspases,
cytochrome,
endothelial cells
About the Authors
T. E. Vladimirskaya
Belarusian Medical Academy of Postgraduate Education
Belarus
Belarus
I. A. Shved
Belarusian Medical Academy of Postgraduate Education
Belarus
Belarus
Yu. E. Demidchik
Belarusian Medical Academy of Postgraduate Education
Belarus
Belarus
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Review
For citations:
Vladimirskaya T.E., Shved I.A., Demidchik Yu.E. Importance of the apoptosis of smooth muscle cells and macrophages of the coronary artery wall in the pathogenesis of atherosclerosis. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(3):69-74. (In Russ.)
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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)
ISSN 2524-2350 (Online)
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