vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-231Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEЗначение апоптоза гладкомышечных клеток и макрофагов стенки коронарной артерии в патогенезе атеросклерозаImportance of the apoptosis of smooth muscle cells and macrophages of the coronary artery wall in the pathogenesis of atherosclerosisВладимирскаяТ. Э.VladimirskayaT. E.tan_2304@inbox.ruШведИ. А.ShvedI. A.noemail@neicon.ruДемидчикЮ. Е.DemidchikYu. E.noemail@neicon.ruБелорусская медицинская академия последипломного образованияBelarusian Medical Academy of Postgraduate Education201506062016036974Copyright © Владимирская Т.Э., Швед И.А., Демидчик Ю.Е., 20162016Владимирская Т.Э., Швед И.А., Демидчик Ю.Е.Vladimirskaya T.E., Shved I.A., Demidchik Y.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/231

При исследовании коронарных артерий умерших от ишемической болезни сердца установлено, что при атеросклерозе происходит как патологическая активация, так и патологическое ингибирование апоптоза основных клеток коронарной артерии с атеросклеротическими повреждениями. Апоптоз гладкомышечных клеток и макрофагов коронарной артерии с атеросклеротическими поражениями реализуется по каспазозависимому механизму. Апоптоз эндотелиальных клеток может происходить как с участием каспаз, так и идти по каспазонезависимому механизму. Наличие умеренной цитоплазматической экспрессии цитохрома с на всех стадиях атерогенеза подтверждает митохондриальную активацию каспазного каскада.

In the investigation of the coronary arteries of the dead from the coronary heart disease, it is found that in atherosclerosis there occur both pathological activation and inhibition of the apoptosis of major cells of the coronary artery with atherosclerotic lesions. The apoptosis of smooth muscle cells and macrophages of coronary artery atherosclerotic lesions is realized by the caspase-dependent mechanism. The apoptosis of endothelial cells can occur with the participation of caspases and by the caspase-independent mechanism. The presence of moderate cytoplasmic expression of cytochrome c in all stages atherogenesis stages confirms the mitochondrial activation of the caspase cascade.

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The authors declare that there are no conflicts of interest present.