Связь сывороточного уровня 25-гидроксивитамина D со стоматологическим статусом, социально-демографическими характеристиками и субъективными жалобами взрослого населения Ташкента

Дефицит витамина D признан глобальной пандемией. Предполагается, что выявление связи между уровнем витамина D, стоматологической патологией, половозрастным и социальным статусом и субъективными жалобами на здоровье необходимо для предварительной диагностики D-гиповитаминоза. Учитывая незначительное число исследований и важность терапии D-гиповитаминоза, целью данного исследования являлась разработка метода его обнаружения на стоматологическом приеме, основанного на комплексной оценке стоматологического, половозрастного и социального статуса пациентов и на их жалобах, а также определение его диагностической информативности. Установлены диагностическая значимость и информативность стоматологического статуса, соматических характеристик и жалоб пациентов при D-гиповитаминозе. При наличии одного из предикторов D-гиповитаминоза вероятность его обнаружения колеблется в пределах от 51,70 до 89,00  %. Вероятность повышения риска развития D-гиповитаминоза при обнаружении у одного пациента двух и более стоматологических патологий высокой интенсивности возрастает до 77,89–92,0 %, при сочетании стоматологической патологии и демографических характеристик ‒ до 88,69–93,00, а при одновременном наличии характерных жалоб ‒ до 95,00 %. Разработана вероятностная модель, позволяющая оценить чувствительность и специфичность диагностических тестов наличия D-гиповитаминоза без привязки к лабораторным методам исследования. Доказана высокая степень информативности комбинированного скрининга с расчетом риска развития D-гиповитаминоза.

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