vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2025-22-3-195-204vestim-1041Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEСвязь сывороточного уровня 25-гидроксивитамина D со стоматологическим статусом, социально-демографическими характеристиками и субъективными жалобами взрослого населения ТашкентаAssociation of serum levels of 25-hydroxyvitamin D with dental status, socio-demographic characteristics and subjective complaints in the adult population of Tashkent cityhttps://orcid.org/0000-0002-7450-3757РубниковичС. П.RubnikovichS. P.

Рубникович Сергей Петрович – д-р мед. наук, профессор, ректор

пр. Дзержинского, 83, 220116, г. Минск, Республика Беларусь

Sergey P. Rubnikovich – D. Sc. (Med.), Professor, Rector

83, Dzerzhinski Ave., 220116, Minsk, Republic of Belarus

rubnikovichs@mail.ruhttps://orcid.org/0000-0002-1686-1820БекжановаО. Е.BekjanovaO. E.

Бекжанова Ольга Есеновна – д-р мед. наук, профессор, заведующий кафедрой

ул. Сайрам, 25, 100170, г. Ташкент, Республика Узбекистан

Olga Е. Bekjanova – D. Sc. (Med.), Professor, Headof the Department

25, Sayram Str., 100170, Tashkent, Republic of Uzbekistan

https://orcid.org/0009-0002-1932-2985МаннановЖ. Ж.MannanovJ. J.

Маннанов Жавлонбек Жамолиддинович – канд. мед.наук, ст. преподаватель

ул. Сайрам, 25, 100170, г. Ташкент, Республика Узбекистан

Javlonbek J. Mannanov – Ph. D. (Med.), senior lecturer

25, Sayram Str., 100170, Tashkent, Republic of Uzbekistan

Белорусский государственный медицинский университетBelarusian State Medical UniversityТашкентский государственный стоматологический институтTashkent State Dental Institute202531082025223195204Copyright © Рубникович С.П., Бекжанова О.Е., Маннанов Ж.Ж., 20252025Рубникович С.П., Бекжанова О.Е., Маннанов Ж.Ж.Rubnikovich S.P., Bekjanova O.E., Mannanov J.J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/1041

Дефицит витамина D признан глобальной пандемией. Предполагается, что выявление связи между уровнем витамина D, стоматологической патологией, половозрастным и социальным статусом и субъективными жалобами на здоровье необходимо для предварительной диагностики D-гиповитаминоза. Учитывая незначительное число исследований и важность терапии D-гиповитаминоза, целью данного исследования являлась разработка метода его обнаружения на стоматологическом приеме, основанного на комплексной оценке стоматологического, половозрастного и социального статуса пациентов и на их жалобах, а также определение его диагностической информативности. Установлены диагностическая значимость и информативность стоматологического статуса, соматических характеристик и жалоб пациентов при D-гиповитаминозе. При наличии одного из предикторов D-гиповитаминоза вероятность его обнаружения колеблется в пределах от 51,70 до 89,00  %. Вероятность повышения риска развития D-гиповитаминоза при обнаружении у одного пациента двух и более стоматологических патологий высокой интенсивности возрастает до 77,89–92,0 %, при сочетании стоматологической патологии и демографических характеристик ‒ до 88,69–93,00, а при одновременном наличии характерных жалоб ‒ до 95,00 %. Разработана вероятностная модель, позволяющая оценить чувствительность и специфичность диагностических тестов наличия D-гиповитаминоза без привязки к лабораторным методам исследования. Доказана высокая степень информативности комбинированного скрининга с расчетом риска развития D-гиповитаминоза.

Vitamin D deficiency is recognized as a global pandemic. The identification of the relationship between hypovitaminosis D, dental pathology, gender and age, and social status, and subjective health complaints may be necessary for a preliminary diagnosis of hypovitaminosis D. Given the limited body of research and the importance of therapy, the main purpose of this research was to develop a method for detecting hypovitaminosis D during dental appointments based on a comprehensive assessment of the dental, gender and age, social status, patient complaints, as well as an evaluation of the diagnostic information these factors provide. The diagnostic significance and informative value of dental status, somatic characteristics, and patient complaints in the diagnosis of hypovitaminosis D have been established. When one of the predictors of hypovitaminosis D is present, the probability of detection ranges from 51.70 to 89.00 %. The detection of two or more high-intensity dental pathologies in a single patient increases this probability to 77.89–92.00 %. The combination of dental pathology with demographic characteristics increases the risk of hypovitaminosis D to 88.69‒93.00 %. The concurrent presence of characteristic complaints increases this risk to 95.00 %. A probabilistic model has been developed to evaluate the sensitivity and specificity of diagnostic tests for the presence of vitamin D deficiency without reference to laboratory research methods. A high degree of informative value of combined screening with the calculation of the risk of vitamin D deficiency has been proven

авитаминоз витамина Dстоматологический статусметод Байесадиагностическая матрица вероятности возникновения заболеваниявоспалительные осложнения после дентальной имплантацииvitamin D deficiencydental statusBayesian methoddiagnostic matrix of the likelihood of the diseaseinflammatory complications after dental implantationReferencesAmr, A. E. H. Vitamin D3 in alveolar bone augmentation performed simultaneously with dental implant placement. A controlled clinical and radiographic study / A. E. H. Amr // Egyptian Dental Journal. – 2019. – Vol. 65, N 4. – P. 3375–3392. https://doi.org/10.21608/edj.2019.74776Amr A. E. H. Vitamin D3 in alveolar bone augmentation performed simultaneously with dental implant placement. A controlled clinical and radiographic study. Egyptian Dental Journal, 2019, vol. 65, no. 4, pp. 3375–3392. https://doi.org/10.21608/edj.2019.74776Clinical identification of geriatric patients with hypovitaminosis D: The “Vitamin D status predictor for geriatrics” study / C. Annweiler, J. Riou, A. Alessandri [et al.] // Nutrients. – 2017. – Vol. 9, N 7. – Art. 658. https://doi.org/10.3390/nu9070658Annweiler C., Riou J., Alessandri A., Gicquel D., Henni S., Féart C., Kabeshova A. Clinical identification of geriatric patients with hypovitaminosis D: The “Vitamin D status predictor for geriatrics” study. Nutrients, 2017, vol. 9, no. 7, art. 658. https://doi.org/10.3390/nu9070658Use of a questionnaire to assess vitamin D status in young adults / J. Bolek-Berquist, M. E. Elliott, R. E. Gangnon [et al.] // Public Health Nutrition. – 2009. – Vol. 12, N 2. – P. 236–243. https://doi.org/10.1017/S136898000800356XBolek-Berquist J., Elliott M. E., Gangnon R. E., Gemar D., Engelke J., Lawrence S. J., Hansen K. E. Use of a questionnaire to assess vitamin D status in young adults. Public Health Nutrition, 2009, vol. 12, no. 2, рр. 236–243. https://doi.org/10.1017/S136898000800356XThe role of vitamins in oral health. A systematic review and meta-analysis / M. G. Cagetti, T. G. Wolf, C. Tennert [et al.] // International Journal of Environmental Research and Public Health. – 2020. – Vol. 17, N 3. – Art. 938. https://doi.org/10.3390/ijerph17030938Cagetti M. G., Wolf T. G., Tennert C., Camoni N., Lingström P., Campus G. The role of vitamins in oral health. A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 2020, vol. 17, no. 3, art. 938. https://doi.org/10.3390/ijerph17030938Increase of vitamin D assays prescriptions and associated factors: a population-based cohort study / P. Caillet, A. Goyer-Joos, M. Viprey, A.-M. Schott // Scientific Reports. – 2017. – Vol. 7, N 1. – Art. 10361. https://doi.org/10.1038/s41598-017-10263-8Caillet P., Goyer-Joos A., Viprey M., Schott A.-M. Increase of vitamin D assays prescriptions and associated factors: a population-based cohort study. Scientific Reports, 2017, vol. 7, no. 1, art. 10361. https://doi.org/10.1038/s41598-017-10263-8Is there an association between vitamin D concentrations and overweight in children and adolescents? / S. R. Coelho, J. C. P. Faria, F. L. A. Fonseca [et al.] // Journal of Tropical Pediatrics. – 2022. – Vol. 68, N 3. – Art. fmac033. https://doi.org/10.1093/tropej/fmac033Coelho S. R., Faria J. C. P., Fonseca F. L. A., de Souza F. I. S., Sarni R. O. S. Is there an association between vitamin D concentrations and overweight in children and adolescents? Journal of Tropical Pediatrics, 2022, vol. 68, no. 3, art. fmac033. https://doi.org/10.1093/tropej/fmac033Quick and easy screening for vitamin D insufficiency in adults: a scoring system to be implemented in daily clinical practice / M. Deschasaux, J.-C. Souberbielle, V. A. Andreeva [et al.] // Medicine. – 2016. – Vol. 95, N 7. – Art. e2783. https://doi.org/10.1097/MD.0000000000002783Deschasaux M., Souberbielle J.-C., Andreeva V. A., Sutton A., Charnaux N., Kesse-Guyot E. [et al.]. Quick and easy screening for vitamin D insufficiency in adults: a scoring system to be implemented in daily clinical practice. Medicine, 2016, vol. 95, no. 7, art. e2783. https://doi.org/10.1097/MD.0000000000002783Prevalence of vitamin D deficiency and its predictors in the Portuguese population: a nationwide population-based study / C. Duarte, H. Carvalheiro, A. M. Rodrigues [et al.] // Archives of Osteoporosis. – 2020. – Vol. 15, N 1. – Art. 36. https://doi.org/10.1007/s11657-020-0695-xDuarte C., Carvalheiro H., Rodrigues A. M., Dias S. S., Marques A., Santiago T., Canhão H., Branco J. C., da Silva J. A. P. Prevalence of vitamin D deficiency and its predictors in the Portuguese population: a nationwide population-based study. Archives of Osteoporosis, 2020, vol. 15, no. 1, art. 36. https://doi.org/10.1007/s11657-020-0695-xVitamin D deficiency in early implant failure: two case reports / T. Fretwurst, S. Grunert, J. P. Woelber [et al.] // International Journal of Implant Dentistry. – 2016. – Vol. 2, N 1. – Art. 24. https://doi.org/10.1186/s40729-016-0056-0Fretwurst T., Grunert S., Woelber J. P., Nelson K., Semper-Hogg W. Vitamin D deficiency in early implant failure: two case reports. International Journal of Implant Dentistry, 2016, vol. 2, no. 1, art. 24. https://doi.org/10.1186/s40729-016-0056-0Comparative evaluation of crestal bone level in patients having low level of vitamin D treated with dental implant with or without vitamin D3 supplements / P. Garg, P. Ghalaut, K. Dahiya [et al.] // National Journal of Maxillofacial Surgery. – 2020. – Vol. 11, N 2. – P. 199–206. https://doi.org/10.4103/njms.NJMS_49_20Garg P., Ghalaut P., Dahiya K., Ravi R., Sharma A., Wakure P. Comparative evaluation of crestal bone level in patients having low level of vitamin D treated with dental implant with or without vitamin D3 supplements. National Journal of Maxillofacial Surgery, 2020, vol. 11, no. 2, pp. 199–206. https://doi.org/10.4103/njms.NJMS_49_20Glossitis with linear lesions: an early sign of vitamin B12 deficiency / J. Graells, R. M. Ojeda, C. Muniesa [et al.] // Journal of the American Academy of Dermatology. – 2009. – Vol. 60, N 3. – P. 498–500. https://doi.org/10.1016/j.jaad.2008.09.011Graells J., Ojeda R. M., Muniesa C., Gonzalez J., Saavedra J. Glossitis with linear lesions: an early sign of vitamin B12 deficiency. Journal of the American Academy of Dermatology, 2009, vol. 60, no. 3, pp. 498–500. https://doi.org/10.1016/j.jaad.2008.09.011Gröber, U. Influence of drugs on vitamin D and calcium metabolism / U. Gröber, K. Kisters // Dermato-Endocrinology. – 2012. – Vol. 4, N 2. – P. 158–166. https://doi.org/10.4161/derm.20731Gröber U., Kisters K. Influence of drugs on vitamin D and calcium metabolism. Dermato-Endocrinology, 2012, vol. 4, no. 2, pp. 158‒166. https://doi.org/10.4161/derm.20731Predicting serum vitamin D concentrations based on self-reported lifestyle factors and personal attributes / V. Ho, C. Danieli, M. Abrahamowicz [et al.] // British Journal of Nutrition. – 2018. – Vol. 120, N 7. – P. 803–812. https://doi.org/10.1017/S000711451800199XHo V., Danieli C., Abrahamowicz M., Belanger A.-S., Brunetti V., Delvin E., Lacaille J., Koushik A. Predicting serum vitamin D concentrations based on self-reported lifestyle factors and personal attributes. British Journal of Nutrition, 2018, vol. 120, no. 7, pp. 803‒812. https://doi.org/10.1017/S000711451800199XHolick, M. F. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention / M. F. Holick // Reviews in Endocrine and Metabolic Disorders. – 2017. – Vol. 18, N 2. ‒ P. 153–165. https://doi.org/10.1007/s11154-017-9424-1Holick M. F. The Vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention. Reviews in Endocrine and Metabolic Disorders, 2017, vol. 18, no. 2, pp. 153–165. https://doi.org/10.1007/s11154-017-9424-1A simple questionnaire for the prediction of vitamin D deficiency in Japanese adults (Vitamin D Deficiency Questionnaire for Japanese: VDDQ-J) / A. Kuwabara, N. Tsugawa, K. Mizuno [et al.] // Journal of Bone and Mineral Metabolism. – 2019. – Vol. 37, N 5. – P. 854–863. https://doi.org/10.1007/s00774-018-0984-2Kuwabara A., Tsugawa N., Mizuno K., Ogasawara H., Watanabe Y., Tanaka K. A simple questionnaire for the prediction of vitamin D deficiency in Japanese adults (Vitamin D Deficiency Questionnaire for Japanese: VDDQ-J). Journal of Bone and Mineral Metabolism, 2019, vol. 37, no. 5, pp. 854–863. https://doi.org/10.1007/s00774-018-0984-2Kwiatek, J. Impact of the 25-hydroxycholecalciferol concentration and vitamin D deficiency treatment on changes in the bone level at the implant site during the process of osseointegration: A prospective, randomized, controlled clinical trial / J. Kwiatek, A. Jaroń, G. Trybek // Journal of Clinical Medicine. – 2021. – Vol. 10, N 3. – Art. 526. https://doi.org/10.3390/jcm10030526Kwiatek J., Jaroń A., Trybek G. Impact of the 25-hydroxycholecalciferol concentration and vitamin D deficiency treatment on changes in the bone level at the implant site during the process of osseointegration: a prospective, randomized, controlled clinical trial. Journal of Clinical Medicine, 2021, vol. 10, no. 3, art. 526. https://doi.org/10.3390/jcm10030526Is low serum vitamin D associated with early dental implant failure? A retrospective evaluation on 1625 implants placed in 822 patients / F. Mangano, C. Mortellaro, N. Mangano, C. Mangano // Mediators of Inflammation. – 2016. – Vol. 2016. – Art. ID 5319718. https://doi.org/10.1155/2016/5319718Mangano F., Mortellaro C., Mangano N., Mangano C. Is low serum vitamin D associated with early dental implant failure? A retrospective evaluation on 1625 implants placed in 822 patients. Mediators of Inflammation, 2016, vol. 2016, art. ID 5319718. https://doi.org/10.1155/2016/5319718Low serum vitamin D and early dental implant failure: is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients / F. G. Mangano, S. Oskouei, A. Paz [et al.] // Journal of Dental Research, Dental Clinics, Dental Prospects. – 2018. – Vol. 12, N 3. – P. 174–182. https://doi.org/10.15171/joddd.2018.027Mangano F. G., Oskouei S., Paz A., Mangano N., Mangano C. Low serum vitamin D and early dental implant failure: is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients. Journal of Dental Research, Dental Clinics, Dental Prospects, 2018, vol. 12, no. 3, pp. 174–182. https://doi.org/10.15171/joddd.2018.027Prediction of insufficient serum vitamin D status in older women: a validated model / T. Merlijn, K. M. A. Swart, P. Lips [et al.] // Osteoporosis International. – 2018. – Vol. 29, N 7. – P. 1539–1547. https://doi.org/10.1007/s00198-018-4410-3Merlijn T., Swart K. M. A., Lips P., Heymans M. W., Sohl E., Van Schoor N. M., Netelenbos C. J., Elders P. J. M. Prediction of insufficient serum vitamin D status in older women: a validated model. Osteoporosis International, 2018, vol. 29, no. 7, pp. 1539–1547. https://doi.org/10.1007/s00198-018-4410-3Association of vitamin D concentrations with subjective health complaints in children and adolescents: the CASPIAN-V study / N. Namazi [et al.] // BMC Public Health. – 2021. – Vol. 21, N 1. – Art. 3. https://doi.org/10.1186/s12889-020-10020-zNamazi N., Qorbani M., Shafiee G., Ahmadian M. H., Motlagh M. E., Ebrahimi M., Asayesh H., Kelishadi R., Heshmat R. Association of vitamin D concentrations with subjective health complaints in children and adolescents: the CASPIAN-V study. BMC Public Health, 2021, vol. 21, no. 1, art. 3. https://doi.org/10.1186/s12889-020-10020-zEffect of vitamin D supplementation on clinical and radiographic evaluation of oral rehabilitation with osseointegrated implants / A. Piccolotto, G. Toyama, M. Busato, A. Y. Togashi // Journal of Health Sciences. – 2019. – Vol. 21. – P. 518–522. https://doi.org/10.17921/2447-8938.2019v21n5p518-522Piccolotto A., Toyama G., Busato M., Togashi A. Y. Effect of vitamin D supplementation on clinical and radiographic evaluation of oral rehabilitation with osseointegrated implants. Journal of Health Sciences, 2019, vol. 21, pp. 518–522. https://doi.org/10.17921/2447-8938.2019v21n5p518-522Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation-a randomized, double-blind, placebo-controlled clinical investigation / U. Schulze-Späte, T. Dietrich, C. Wu [et al.] // Clinical Oral Implants Research. – 2015. – Vol. 27, N 6. – P. 701–706. https://doi.org/10.1111/clr.12641Schulze-Späte U., Dietrich T., Wu C., Wang K., Hasturk H., Dibart S. Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation-a randomized, double-blind, placebo-controlled clinical investigation. Clinical Oral Implants Research, 2015, vol. 27, no. 6, pp. 701–706. https://doi.org/10.1111/clr.12641Evaluation of fall sun exposure score in predicting vitamin D status in young Canadian adults, and the influence of ancestry / L. Sham, E. A. Yeh, S. Magalhaes [et al.] // Journal of Photochemistry and Photobiology B. – 2015. – Vol. 145. – P. 25–29. https://doi.org/10.1016/j.jphotobiol.2015.02.007Sham L., Yeh E. A., Magalhaes S., Parra E. J., Gozdzik A., Banwell B., Hanwell H. E. Evaluation of fall sun exposure score in predicting vitamin D status in young Canadian adults, and the influence of ancestry. Journal of Photochemistry and Photobiology B, 2015, vol. 145, pp. 25–29. https://doi.org/10.1016/j.jphotobiol.2015.02.007Vitamin D levels and deficiency with different occupations: a systematic review / D. Sowah, X. Fan, L. Dennett [et al.] // BMC Public Health. – 2017. – Vol. 17, N 1. – Art. 519. https://doi.org/10.1186/s12889-017-4436-zSowah D., Fan X., Dennett L., Hagtvedt R., Straube S. Vitamin D levels and deficiency with different occupations: a systematic review. BMC Public Health, 2017, vol. 17, no. 1, art. 519. https://doi.org/10.1186/s12889-017-4436-zDeterminants of vitamin D status in young adults: influence of lifestyle, sociodemographic and anthropometric factors / R. Tønnesen, P. H. Hovind, L. T. Jensen, P. Schwarz // BMC Public Health. – 2016. – Vol. 16. – Art. 385. https://doi.org/10.1186/ s12889-016-3042-9Tønnesen R., Hovind P. H., Jensen L. T., Schwarz P. Determinants of vitamin D status in young adults: influence of lifestyle, sociodemographic and anthropometric factors. BMC Public Health, 2016, vol. 16, art. 385. https://doi.org/10.1186/s12889-016-3042-9Development of an algorithm to predict serum vitamin D levels using a simple questionnaire based on sunlight exposure / E. Vignali, E. Macchia, F. Cetani [et al.] // Endocrine. – 2017. – Vol. 55, N 1. – P. 85–92. https://doi.org/10.1007/s12020-016-0901-1Vignali E., Macchia E., Cetani F., Reggiardo G., Cianferotti L., Saponaro F., Marcocci C. Development of an algorithm to predict serum vitamin D levels using a simple questionnaire based on sunlight exposure. Endocrine, 2017, vol. 55, no. 1, pp. 85–92. https://doi.org/10.1007/s12020-016-0901-1Development and validation of a predictive model of hypovitaminosis D in general adult population: SCOPYD study / M. Viprey, B. Merle, B. Riche [et al.] // Nutrients. – 2021. – Vol. 13, N 8. – Art. 2526. https://doi.org/10.3390/nu13082526Viprey M., Merle B., Riche B., Freyssenge J., Rippert P., Chakir M. A. [et al.]. Development and validation of a predictive model of hypovitaminosis D in general adult population: SCOPYD study. Nutrients, 2021, vol. 13, no. 8, art. 2526. https://doi.org/10.3390/nu13082526Risk factors generally neglected in oral surgery and implantology: the high LDL-cholesterol and the insufficient level of vitamin D / K. Waskiewicz, O. Oth, N. Kochan, L. Evrard // Revue Médicale de Bruxelles. – 2018. – Vol. 39, N 2. – P. 70–77. https://doi.org/10.30637/2018.17-075Waskiewicz K., Oth O., Kochan N., Evrard L. Risk factors generally neglected in oral surgery and implantology: the high LDL-cholesterol and the insufficient level of vitamin D. Revue Médicale de Bruxelles, 2018, vol. 39, no. 2, pp. 70–77. https://doi.org/10.30637/2018.17-075

The authors declare that there are no conflicts of interest present.