Печеночно-интестинальная ось: физиология сквозь призму микробиома

В данной работе представлено краткое историческое описание эволюции взглядов на развитие концепции функционирования печеночно-интестинальной оси и ее физиологии. Описаны и обсуждены основные принципы физиологического функционирования нового, «виртуального», органа человека и их роль в патогенезе заболеваний печени, в том числе после перенесенной трансплантации печени.

Приведены полученные нами данные о секвенировании нового поколения, дающие представление о микробиомной палитре пациентов, страдающих хроническими диффузными заболеваниями печени различной этиологии. Cобственное исследование было представлено на основании изучения данных 12 обследованных в пред- и посттрансплантационном периоде пациентов, страдающих хроническими диффузными поражениями печени. Полученные результаты свидетельствуют о важном значении микробиома кишечника в естественном процессе реконвалесценции после перенесенной трансплантации печени.

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