Effects of fatty acid amides with ethanolamine and glycine on nociceptive reactions and gait parameters in rats in normal and experimental peripheral mononeuropathy
https://doi.org/10.29235/1814-6023-2022-19-4-364-374
Abstract
The effects of fatty acid amides ethanolamine and glycine on gait patterns and nociceptive reactions was investigated after injections of these fatty acid derivatives in healthy rats and in rats with experimental peripheral neuropathy. It has been proven that palmitoylethanolamide and the stearoylethanolamide are more effective at relieving neuropathic pain and restoring gait parameters than glycine palmitamide.
About the Authors
A. S. Doronkina
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Anastasya S. Doronkina – Postgraduate student, Junior Researcher, Institute of Physiology of the National Academy of Sciences of Belarus.
28, Akademicheskaya Str., 220072, Minsk
A. L. Mikhalchuk
Institute of Bioоrganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Alexander L. Mikhalchuk – Ph. D. (Chem.), Leading Researcher, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Akademik Kuprevich Str., 220141, Minsk
S. V. Goubkin
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Sergey V. Goubkin – Corresponding Member, D. Sc. (Med.), Professor, Director, Institute of Physiology of the National Academy of Sciences of Belarus.
28, Akademicheskaya Str., 220072, Minsk
A. Yu. Molchanova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Alla Ju. Molchanova – Ph. D. (Biol.), Head of the Laboratory, Institute of Physiology of the National Academy of Sciences of Belarus.
28, Akademicheskaya Str., 220072, Minsk
V. G. Bogdan
Department of Medical Sciences of the National Academy of Sciences of Belarus
Belarus
Belarus
Vasily G. Bogdan – D. Sc. (Med.), Professor, Academician-Secretary of the Department of Medical Sciences of the National Academy of Sciences of Belarus.
66, Nezavisimosti Ave., 220072, Minsk
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Review
For citations:
Doronkina A.S., Mikhalchuk A.L., Goubkin S.V., Molchanova A.Yu., Bogdan V.G. Effects of fatty acid amides with ethanolamine and glycine on nociceptive reactions and gait parameters in rats in normal and experimental peripheral mononeuropathy. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2022;19(4):364-374. (In Russ.) https://doi.org/10.29235/1814-6023-2022-19-4-364-374
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