Effect of quercetin and its combination with cyclodextrin on the healing of full-thickness skin wounds in laboratory rats
A. A. Bakunovich,
V. U. Buko,
A. A. Sidarovich,
A. B. Astrowskaya,
V. L. Maroz,
Yu. V. Yarashenka,
A. A. Astrowski
https://doi.org/10.29235/1814-6023-2022-19-2-219-229
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Abstract
Macroscopic, histological, electron microscopic, microbiological, and immunological methods were used to study the healing of full-thickness skin wounds in laboratory rats under the influence of quercetin and its complex with 2-hydroxypropyl-β-cyclodextrin. It was revealed that under the influence of quercetin, the wound was completely covered with the epidermis almost a day earlier than in the control, and under the influence of a complex with 2-hydroxypropylβ-cyclodextrin 2.2 days earlier (p < 0.02). This was mainly due to the acceleration of marginal epidermization. There was no positive effect on the wound contraction. Quercetin and especially its complex with cyclodextrin had a stimulating effect on the phagocytic and metabolic activity of neutrophils both on the wound surface and in the blood of animals. The bacterial microflora present on the wound surface during healing coincided with the microflora of the intact skin. Neither the quercetin, nor the quercetin-2-hydroxypropyl-β-cyclodextrin significantly affected its composition.
About the Authors
A. A. Bakunovich
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
Aliaksei A. Bakunovich – Junior Researcher
50, BLK, 230030, Grodno
V. U. Buko
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
Vyachaslau U. Buko – D. Sc. (Biol.), Professor, Head of the Department
50, BLK, 230030, Grodno
A. A. Sidarovich
Grodno State Medical University
Belarus
Belarus
Alena A. Sidarovich – Assistant
80, Gorky Str., 230009, Grodno
A. B. Astrowskaya
Grodno State Medical University
Belarus
Belarus
Aksana B. Astrowskaja – Ph. D. (Biol.), Associate Professor, Senior Researcher
80, Gorky Str., 230009, Grodno
V. L. Maroz
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
Valiantsina L. Maroz – Researcher
50, BLK, 230030, Grodno
Yu. V. Yarashenka
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
Yulia V. Yarashenka – Junior Researcher
50, BLK, 230030, Grodno
A. A. Astrowski
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
Belarus
Belarus
Aliaksandr A. Astrowski – D. Sc. (Med.), Professor, Leading Researcher
50, BLK, 230030, Grodno
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Review
For citations:
Bakunovich A.A., Buko V.U., Sidarovich A.A., Astrowskaya A.B., Maroz V.L., Yarashenka Yu.V., Astrowski A.A. Effect of quercetin and its combination with cyclodextrin on the healing of full-thickness skin wounds in laboratory rats. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2022;19(2):219-229. (In Bel.) https://doi.org/10.29235/1814-6023-2022-19-2-219-229
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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)
ISSN 2524-2350 (Online)
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