Influence of glucocorticoid hormones on the thyroid gland function
https://doi.org/10.29235/1814-6023-2021-18-1-117-126
Abstract
The injection of exogenous analogues of glucocorticoid hormones (cortisone, hydrocortisone, corticosterone, dexamethasone, betamethasone, etc.) leads to a change in thyroid function at all levels (biosynthesis and secretion of hormones by the thyroid gland, the transport, interaction with receptors in target organs, biological action, their metabolism and excretion). Glucocorticoid hormones change regulationof the thyroid function: transhypophysially (glucocorticoids block the secretion of thyroliberin, thyroid stimulating hormone, corticotropin releasing hormone, somatoliberin and the production of somatotropin under the influence of the last one) and parahypophysially (glucocorticoids stimulate formation of insulin in β-cells of the pancreas).
About the Authors
E. A. Gusakova
Vitebsk State Order of Peoples’ Friendship Medical University
Belarus
Belarus
Elena A. Gusakova ‒ Ph. D. (Biol.), Associate Professor
27, Frunze Ave., 210017, Vitebsk, Republic of Belarus
I. V. Gorodetskaya
Vitebsk State Order of Peoples’ Friendship Medical University
Belarus
Belarus
Irina V. Gorodetskaya ‒ D. Sc. (Med.), Professor, Dean
27, Frunze Ave., 210017, Vitebsk, Republic of Belarus
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Review
For citations:
Gusakova E.A., Gorodetskaya I.V. Influence of glucocorticoid hormones on the thyroid gland function. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2021;18(1):117-126. (In Russ.) https://doi.org/10.29235/1814-6023-2021-18-1-117-126
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