A comprehensive program of optimization the brain oxygen status in newborns with respiratory disorders based on targeting regional oxygenation

NIRS provides the ability to obtain information about the brain oxygen status non-invasively. Therefore, potentially, this technology can make it possible to correct therapy that affects the blood and oxygen supply to the brain.

The aim of our study was to develop a guideline for a dynamic monitoring of the oxygen status based on regional oxygenation data, as well as an effective therapeutic tool for newborns with respiratory distress.

78 newborns with respiratory disorders were included (37 late preterm and 41 full-term) in this observational cohort study. In addition to a standard cardiorespiratory monitoring, a simultaneous monitoring of abdominal and cerebral oxygenation was performed during the early neonatal period.

The developed treatment guideline was based on a multisystem approach in diagnosis and optimization of the brain oxygen delivery and consumption. The proposed algorithm focused on maintaining an adequate perfusion pressure, cardiac output, oxygen, and carbon dioxide content in the arterial blood in newborns with respiratory disorders.

Implementing the developed treatment guideline in the neonatal intensive care units should increase the treatment effectiveness in newborns with respiratory disorders.

Implementation developed treatment guideline in the neonatal intensive care units should increase the effectiveness of treatment in newborns with respiratory disorders.