Morphological diversity of vulvar lichen sclerosus
https://doi.org/10.29235/1814-6023-2019-16-3-357-364
Abstract
Vulvar lichen sclerosus (LS) is a common chronic mucocutaneous disease, which is usually underdiagnosed and tend to progress without adequate treatment.
Morphological characteristics of vulvar LS with unusual histological features.
Vulvar biopsy material (n = 83) with morphologically diagnosed LS was examined histologically and statistically.
Often saw-toothed modification of the epithelium, fibrinoid necrosis, cytoid bodies, satellite cell necrosis, hemorrhages, papillomatosis, milia, predominantly plasma cell inflammatory infiltrate, lymphoid follicles, elastosis, angiokeratoma-like vasculare change were found on the background vulvar LS.
Saw-tooth epidermal change, multiple cytoid bodies and satellite cell necrosis are histological features of LS described for the first time in this study, the former being a frequent presentation of vulvar LS. The mentioned above histological changes cannot appear as features in favor of lichen planus in the differential diagnosis of these diseases.
About the Authors
Y. A. Kuzmenka-Maskvina
City Clinical Pathology Bureau, Minsk
Belarus
Belarus
Yuliya A. Kuzmenka-Maskvina – Рathologist
8/8, Semashko Str., Minsk
T. A. Bich
Belаrusian State Medical University
Belarus
Belarus
Tatjana A. Bich – Ph. D. (Med.), Assistant professor
83, Dzerzhynskii Ave., 220116, Minsk
Z. N. Bragina
Belаrusian State Medical University
Belarus
Belarus
Zoya N. Bragina – Ph. D. (Med.), Assistant professor
83, Dzerzhynskii Ave., 220116, Minsk
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Review
For citations:
Kuzmenka-Maskvina Y.A., Bich T.A., Bragina Z.N. Morphological diversity of vulvar lichen sclerosus. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(3):357-364. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-3-357-364
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