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Proceedings of the National Academy of Sciences of Belarus, Medical series

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Diagnostic significance of biomarkers of the epileptic seizures development in patients with arterial aneurysms

https://doi.org/10.29235/1814-6023-2019-16-3-324-331

Abstract

The aim of the study was to establish the diagnostic significance of biochemical parameters, considered as markers of epileptic seizures in patients with arterial aneurysms (AA). 82 patients with AA (50.4 ± 11.5 year-old) with epileptic seizures (35 persons) and without them (47 persons) were examined. Before treatment, the following biochemical parameters were determined in plasma of patients: lactate, pyruvate, products reacting with thiobarbituric acid (TBA-P), antioxidant activity of the serum, activity of superoxidedismutase and catalase, tumor necrosis factor-alpha (TNF-ά). To characterize the diagnostic significance of the results, the diagnostic sensitivity and the diagnostic efficacy were determined. The complex of biochemical tests with high diagnostic significance, consisting of lactate, lactate/pyruvateindex, catalase activity, TBA-P and TNF-α, was established in patients with AA with epileptic seizures. It allows considering these parameters as markers of epileptic seizures development in patients with AA. Among the most diagnostically significant tests for detection of epileptic seizures in patients with AA should be considered the concentration of TNF-ά with diagnostic sensitivity of 73%, the diagnostic specificity of 79% and the diagnostic efficacy of 75%.

About the Authors

N. I. Nechipurenko
Republican Research and Clinical Center of Neurology and Neurosurgery
Belarus

Natalia I. Nechipurenko – D. Sc. (Med.), Professor, Head of the Laboratory

24, F. Skorina Str., 220114, Minsk



R. R. Sidorovich
Republican Research and Clinical Center of Neurology and Neurosurgery
Belarus

Ryszard R. Sidorovich – D. Sc. (Med.), Assistant Professor, Director

24, F. Skorinа Str., 220114, Minsk



I. D. Pashkovskaya
Republican Research and Clinical Center of Neurology and Neurosurgery
Belarus

Irina D. Pashkovskaya – Ph. D. (Biol.), Leading researcher

24, F. Skorinа Str., 220114, Minsk



Y. I. Stepanova
Republican Research and Clinical Center of Neurology and Neurosurgery
Belarus

Yulia I. Stepanova – Ph. D. (Med.), Assistant Professor

24, F. Skorinа Str., 220114, Minsk



O. L. Zmachinskaya
Republican Research and Clinical Center of Neurology and Neurosurgery
Belarus

Olga L. Zmachynskaya – Researcher

F. Skоryna Str., 24, 220114, Minsk



T. A. Prokopenko
Republican Research and Clinical Center of Neurology and Neurosurgery
Belarus

Tatiana A. Prokopenko – Junior researcher

24, F. Skorinа Str., 220114, Minsk



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Review

For citations:


Nechipurenko N.I., Sidorovich R.R., Pashkovskaya I.D., Stepanova Y.I., Zmachinskaya O.L., Prokopenko T.A. Diagnostic significance of biomarkers of the epileptic seizures development in patients with arterial aneurysms. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(3):324-331. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-3-324-331

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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)