Chronic intoxication with liposomal fatty acid amides in the experiment
https://doi.org/10.29235/1814-6023-2019-16-2-142-150
Abstract
The derivatives of fatty acids are considered as promising bases for the development of medicinal and cosmetic agents. In this regard, it is necessary to study their potential toxicity, including chronic. In repeated toxicity experiments on mice of C57BL6 line, the administration of N-palmitoyl-5-aminolevulinic acid (within liposomes) for 62 days was less toxic than N-palmitoylglycine injected in the same regimen, which resulted in lower mortality of animals. The toxic effects of high doses, both PalGly and Pal-5-ALA, are characterized by a gender dependence: males were more sensitive to PalGly, whereas females - to Pal-5-Ala. Chronic administration of liposomes of phosphatidylcholine (without N-acylamino acids) caused the death of several mice, suggesting that the toxic effects of PalGly and Pal-5-ALA in liposomal form are at least partly due to the influence of the liposomes themselves.
About the Authors
O. A. Antipova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Olga A. Antipova – Junior researcher
28, Akademicheskaya Str., 220072, Minsk
I. P. Zhavoronok
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Irina P. Zhavoronok – Ph. D. (Biol.), Senior researcher
28, Akademicheskaya Str., 220072, Minsk
T. O. Pavlut
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Tatjana O. Pavlut – Researcher
28, Akademicheskaya Str., 220072, Minsk
E. I. Pehtereva
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Elena I. Pehtereva – Junior researcher
28, Akademicheskaya Str., 220072, Minsk
T. B. Melik-Kasumov
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Tigran B. Melik-Kasumov – Ph. D. (Biol.), Leading researcher, Head of the Laboratory
28, Akademicheskaya Str., 220072, Minsk
S. A. Kodalenkova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Svetlana A. Kodalenkova – Junior researcher
28, Akademicheskaya Str., 220072, Minsk
A. L. Mihal’chuk
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Aleksandr L. Mihal’chuk – Ph. D. (Chem.), Leading researcher, Deputy Head of the Laboratory
5/2, Kuprevich Str., 220141, Minsk
M. A. Kisel
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Mihail A. Kisel – D. Sc. (Chem.), Head of the Laboratory
5/2, Kuprevich Str., 220141, Minsk
A. Yu. Molchanova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Alla Y. Molchanova – Ph. D. (Biol.), Senior researcher, Head of the Laboratory
28, Akademicheskaya Str., 220072, Minsk
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Review
For citations:
Antipova O.A., Zhavoronok I.P., Pavlut T.O., Pehtereva E.I., Melik-Kasumov T.B., Kodalenkova S.A., Mihal’chuk A.L., Kisel M.A., Molchanova A.Yu. Chronic intoxication with liposomal fatty acid amides in the experiment. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(2):142-150. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-2-142-150
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