Механизмы повреждения ацинарных клеток поджелудочной железы при остром алкогольном панкреатите
https://doi.org/10.29235/1814-6023-2019-16-1-108-116
Аннотация
В обзоре представлен анализ современных сведений об основных механизмах токсичного воздействия алкоголя и его метаболитов на ацинарные клетки поджелудочной железы при остром панкреатите. Показано, что механизмы клеточного повреждения многокомпонентны и тесно взаимосвязаны регуляторными факторами молекулярного уровня. На ранней стадии заболевания они приводят к следующим структурно-функциональным изменениям ацинарных клеток, способствующим преждевременной внутриклеточной активации трипсиногена и аутоагрессии: устойчивому подъему цитозольного Ca2+ и избытку митохондриального Cа2+, дестабилизации лизосом и зимогенных гранул, нарушению аутофагии, деполяризации митохондрий, снижению выработки АТФ и некрозу.
Об авторе
Л. А. Можейко
Гродненский государственный медицинский университет
Беларусь
Беларусь
Можейко Лариса Андреевна – кандидат медицинских наук, доцент
ул. Горького, 80, 230015, г. Гродно
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Рецензия
Для цитирования:
Можейко Л.А. Механизмы повреждения ацинарных клеток поджелудочной железы при остром алкогольном панкреатите. Известия Национальной академии наук Беларуси. Серия медицинских наук. 2019;16(1):108-116. https://doi.org/10.29235/1814-6023-2019-16-1-108-116
For citation:
Mozheiko L.A. Mechanisms of damage of acinar pancreatic cells in acute alcohol pancreatitis. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(1):108-116. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-1-108-116
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