Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen
https://doi.org/10.29235/1814-6023-2019-16-1-56-64
Abstract
The hepatoprotective effect of the self-emulsifying composition with berberine was studied in the model of toxic liver damage in rats with acetaminophen and its hepatoprotective properties were analyzed in comparison with the use of berberine in free form. The course introduction of self-emulsifying composition with berberine before intoxication of rats with acetaminophen to a greater extent inhibits the development of cytolysis of hepatocytes, and also promotes the enhancement of the glutathione unit of the antioxidant system, increasing the content of total and free sulfhydryl groups, compared with the introduction of free berberine in animals.
About the Authors
I. P. Sutsko
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belaru
Belarus
Belarus
Iryna P. Sutsko – Ph. D. (Biol.), Senior researcher
50, Lenin Komsomol Boulevard, 230030, Grodno
A. G. Shlyahtun
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belaru
Belarus
Belarus
Alexej G. Shlyahtun – Researcher, Acting Head of the Department
50, Lenin Komsomol Boulevard, 230030, Grodno
O. V. Titko
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belaru
Belarus
Belarus
Oksana V. Titko – Junior researcher
50, Lenin Komsomol Boulevard, 230030, Grodno
N. V. Yankevich
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belaru
Belarus
Belarus
Nadezhda V. Yankevich – Researcher
50, Lenin Komsomol Boulevard, 230030, Grodno
P. G. Telegin
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belaru
Belarus
Belarus
Pavel G. Telegin – Junior researcher
50, Lenin Komsomol Boulevard, 230030, Grodno
A. V. Kolodko
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belaru
Belarus
Belarus
Anastasia V. Kolodko – Junior researcher
50, Lenin Komsomol Boulevard, 230030, Grodno
I. V. Zverinsky
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belaru
Belarus
Belarus
Igor V. Zverinsky – Ph. D. (Biol.), Head of the Department
50, Lenin Komsomol Boulevard, 230030, Grodno
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Review
For citations:
Sutsko I.P., Shlyahtun A.G., Titko O.V., Yankevich N.V., Telegin P.G., Kolodko A.V., Zverinsky I.V. Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2019;16(1):56-64. (In Russ.) https://doi.org/10.29235/1814-6023-2019-16-1-56-64
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