Regulatory and therapeutic potential for obesity
https://doi.org/10.29235/1814-6023-2018-15-4-483-492
Abstract
About the Authors
O. E. PoluliakhBelarus
Researcher
E. I. Kalinovskaya
Belarus
Ph. D. (Med), Head of the Laboratory
A. A. Basalai
Belarus
Junior researcher
References
1. Lin Q., Gao Z., Alarcon R. M., Ye J., Yun Z. A role of miR-27 in the regulation of adipogenesis. FEBS Journal, 2009, vol. 276, no. 8, pp. 2348–2358. https://doi.org/10.1111/j.1742-4658.2009.06967.x
2. Klöting N., Berthold S., Kovacs P., Schön M. R., Fasshauer M., Ruschke K., Stumvoll M., Blüher M. MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS ONE, 2009, vol. 4, no. 3, pp. e4699. https://doi.org/ 10.1371/journal.pone.0004699
3. Cherevko А. N., Girko I. N., Perkovskaya А. F. The problem of obesity in the adult population of the Republic of Belarus: age, gender and social aspect. Voprosy organizatsii i informatizatsii zdravookhraneniya [Issues of organization and information health], 2015, no. 3, pp. 68–70 (in Russian).
4. Kang J. G., Park Ch.-Y. Anti-obesity drugs: a review about their effects and safety. Diabetes and Metabolism Journal, 2012, vol. 36, no. 1, pp. 13–25. https://doi.org/10.4093/dmj.2012.36.1.13
5. Litvinova L. S., Kirienkova E. V., Mazunin I. O., Vasilenko M. A., Fattakhov N. S. Pathogenesis of insulin resistance in metabolic obesity. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2015, vol. 8, no. 3, pp. 192–202.
6. Lewis B. P., Burge C. B., Bartel D. P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 2005, vol. 120, no. 1, pp. 15–20. https://doi.org/10.1016/j.cell.2004.12.035
7. Arner P., Kulyté A. MicroRNA regulatory networks in human adipose tissue and obesity. Nature Reviews Endocrinology, 2015, vol. 11, no. 5, pp. 276–288. https://doi.org/10.1038/nrendo.2015.25
8. Akushev V. N. MicroRNA: small molecules with great importance. Klinicheskaya onkogematologiya. Fundamental’nye issledovaniya i klinicheskaya praktika [Clinical Oncohematology. Basic Research and Clinical Practice], 2015, vol. 8, no. 1, pp. 1–12 (in Russian).
9. Davis B. N., Hilyard A. C., Lagna G., Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature, 2008, vol. 454, no. 7200, pp. 56–61. https://doi.org/10.1038/nature07086
10. Guil S., Cáceres J. F. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nature Structural and Molecular Biology, 2007, vol. 14, no.7, pp. 591–596. https://doi.org/10.1038/nsmb1250
11. Kedde M., Strasser M. J., Boldajipour B., Vrielink J. A. F. O., Slanchev K., Sage C. et al. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell, 2007, vol. 131, no. 7, pp. 1273–1286. https://doi.org/10.1016/j.cell.2007.11.034
12. Lin R.-J., Lin Y.-C., Chen J., Kuo H.-H., Chen Y.-Y., Diccianni M. B., London W. B., Chang C.-H., Yu A. L. MicroRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Research, 2010, vol. 70, no. 20, pp. 7841–7850. https://doi.org/10.1158/0008-5472.can-10-0970
13. Xu P., Vernooy S. Y., Guo M., Hay B. A. The drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Current Biology, 2003, vol. 13, no. 9, pp. 790–795. https://doi.org/10.1016/s0960-9822(03)00250-1
14. Teleman A. A., Cohen S. M. Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes and Development, 2006, vol. 20, no. 4, pp. 417–422. https://doi.org/10.1101/gad.374406
15. Esau C., Kang X., Peralta E., Hanson E., Marcusson E. G., Ravichandran L. V. et al. MicroRNA-143 regulates adipocyte differentiation. Journal of Biological Chemistry, 2004, vol. 279, no. 50, pp. 52361–52365. https://doi.org/10.1074/jbc.c400438200
16. Tofilo М. А., Egorova Е. N. MicroRNA, regulating adipogenesis in type 2 diabetes mellitus. Zdorov’e i obrazovanie v XXI veke = Health & education millennium, 2017, vol. 19, no. 3, pp. 108–111 (in Russian).
17. Xie H., Lim B., Lodish H. F. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes, 2009, vol. 58, no. 5, pp. 1050–1057. https://doi.org/10.2337/db08-1299
18. Gerin I., Bommer G. T., McCoin C. S., Sousa K. M., Krishnan V., MacDougald O. A. Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. American Journal of Physiology-Endocrinology and Metabolism, 2010, vol. 299, no. 2, pp. E198–E206. https://doi.org/10.1152/ajpendo.00179.2010
19. Xie H., Sun L., Lodish H. F. Targeting microRNAs in obesity. Expert Opinion on Therapeutic Targets, 2009, vol. 13, no. 10, pp. 1227–1238. https://doi.org/10.1517/14728220903190707
20. Kennell J. A., Gerin I., MacDougald O. A., Cadigan K. M. The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proceedings of the National Academy of Sciences, 2008, vol. 105, no. 40, pp. 15417–15422. https://doi.org/10.1073/pnas.0807763105
21. Wang Q., Li Y. C., Wang J., Kong J., Qi Y., Quigg R. J., Li X. MiR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proceedings of the National Academy of Sciences, 2008, vol. 105, no. 8, pp. 2889–2894. https://doi.org/10.1073/pnas.0800178105
22. Zhou X., Benson K. F., Ashar H. R., Chada K. Mutation responsible for the mouse pygmy phenotype in the deve lopmentally regulated factor HMGI-C. Nature, 1995, vol. 376, no. 6543, pp. 771–774. https://doi.org/10.1038/376771a0
23. Sun T., Fu M., Bookout A. L., Kliewer S. A., Mangelsdorf D. J. MicroRNA let-7 regulates 3T3-L1 adipogenesis. Molecular Endocrinology, 2009, vol. 23, no. 6, pp. 925–931. https://doi.org/10.1210/me.2008-0298
24. Zhu H., Shyh-Chang N., Segrè A. V., Shinoda G., Shah S. P., Einhorn W. S. et al. The Lin28/let-7 axis regulates glucose metabolism. Cell, 2011, vol. 147, no. 1, pp. 81–94. https://doi.org/10.1016/j.cell.2011.08.033
25. Lin Q., Gao Z., Alarcon R. M., Ye J., Yun Z. A role of miR-27 in the regulation of adipogenesis. FEBS Journal, 2009, vol. 276, no. 8, pp. 2348–2358. https://doi.org/10.1111/j.1742-4658.2009.06967.x
26. Egorov А. D., Pen’kov D. N., Tkachuk V. А. Molecular and cellular mechanisms of adipogenesis. Sakharnyi diabet [Diabetes mellitus], 2015, vol. 18, no. 2, pp. 12–19 (in Russian).
27. Tang Y.-F., Zhang Y., Li X.-Y., Li C., Tian W., Liu L. Expression of miR-31, miR-125b-5p, and miR-326 in the adipogenic differentiation process of adipose-derived stem cells. OMICS: A Journal of Integrative Biology, 2009, vol. 13, no. 4, pp. 331–336. https://doi.org/10.1089/omi.2009.0017
28. Nóbrega C., Rodriguez-López R. (eds). Molecular mechanisms underpinning the development of obesity. Basel, Springer, 2014. 194 p.
29. Heneghan H. M., Miller N., McAnena O. J., O’Brien T., Kerin M. J. Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers. Journal of Clinical Endocrinology and Metabolism, 2011, vol. 96, no. 5, pp. E846–E850. https://doi.org/10.1210/jc.2010-2701
30. Ge Q., Brichard S., Yi X., QiFu Li. MicroRNAs as a new mechanism regulating adipose tissue inflammation in obesity and .as a novel therapeutic strategy in the metabolic syndrome. Journal of Immunology Research, 2014, vol. 2014, art. ID 987285. https://doi.org/10.1155/2014/987285
31. Esau C., Davis S., Murray S. F., Xing Xian Yu, Pandey S. K., Pear M. et al. MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metabolism, 2006, vol. 3, no. 2, pp. 87–98. https://doi.org/10.1016/j.cmet.2006.01.005
32. Rotlan N., Price N., Pati P., Goedeke L., Fernández-Hernando C. MicroRNAs in lipoprotein metabolism and cardiometabolic disorders. Atherosclerosis, 2016, vol. 246, pp. 352–360. https://doi.org/10.1016/j.atherosclerosis.2016.01.025
33. McGregor R. A., Choi M. S. MicroRNAs in the regulation of adipogenesis and obesity. Current Molecular Medicine, 2011, vol. 11, no. 4, pp. 304–316. https://doi.org/10.2174/156652411795677990
Review
For citations:
Poluliakh O.E., Kalinovskaya E.I., Basalai A.A. Regulatory and therapeutic potential for obesity. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(4):483-492. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-4-483-492