ANTINOCYCEPTIVE EFFECT OF A SYSTEMIC ADMINISTRATION OF PALMITOYLETHANOLAMIDE, STEAROYLETHANOLAMIDE AND DYNCLOFENAC IN RATS WITH EXPERIMENTAL NEUROGENIC PAIN SYNDROME
A. Iu. Molchanova,
I. P. Zhavoronok,
E. I. Pekhtereva,
O. A. Antipova,
T. B. Melik-Kasumov,
T. O. Pavlyut’,
A. I. Vasil’kevich,
M. A. Kisel’
https://doi.org/10.29235/1814-6023-2018-15-3-331-
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Abstract
The antinociceptive effect of palmitoylethanolamide (PEA), stearoyl- ethanolamide (SEA) and sodium diclofenac in experimental peripheral neuropathy in rats was studied. Intraperitoneal administration of PEA one hour prior to stimulation on the 7th and 14th day significantly weakened CCI-induced mechanical hyperalgesia by increasing PNR by 23.1 and 31.8 %, respectively. SEA under similar conditions increased PNR by 27.9 and 30.3 %, while diclofenac – by 29.0 and 26.2 %. New data were obtained and pointed that stearoylethanolamide effectively weakens mechanical hyperalgesia caused by neuropathy. The antinociceptive effects of these fatty acid derivatives in the modeling of neurogenic pain syndrome are comparable to those of sodium diclofenac. It seems advisable to consider PEA and SEA as a basis for drugs, whose addition to treatment regimens of neuropathic pain will increase its effectiveness.
About the Authors
A. Iu. Molchanova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Alla Ju. Molchanova – Ph. D. (Biol.), Head of the Laboratory
28, Akademicheskaya Str., 220072, Minsk
I. P. Zhavoronok
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Irina P. Zhavoronok – Ph. D. (Biol.), Senior researcher
28, Akademicheskaya Str., 220072, Minsk
E. I. Pekhtereva
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Elena I. Pekhtereva – Junior researcher
28, Akademicheskaya Str., 220072, Minsk
O. A. Antipova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Ol’ga A. Antipova – Junior researcher
28, Akademicheskaya Str., 220072, Minsk
T. B. Melik-Kasumov
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Tigran B. Melik-Kasumov – Ph. D. (Biol.), Senior researcher
28, Akademicheskaya Str., 220072, Minsk
T. O. Pavlyut’
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Tat’yana O. Pavlyut’ – Researcher
28, Akademicheskaya Str., 220072, Minsk
A. I. Vasil’kevich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Aleksey I. Vasil’kevich – Researcher
5/2, Kuprevich Str., 220141, Minsk
M. A. Kisel’
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Mikhail A. Kisel’ – D. Sc. (Chem.), Professor, Head of the Laboratory
5/2, Kuprevich Str., 220141, Minsk
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Review
For citations:
Molchanova A.I., Zhavoronok I.P., Pekhtereva E.I., Antipova O.A., Melik-Kasumov T.B., Pavlyut’ T.O., Vasil’kevich A.I., Kisel’ M.A. ANTINOCYCEPTIVE EFFECT OF A SYSTEMIC ADMINISTRATION OF PALMITOYLETHANOLAMIDE, STEAROYLETHANOLAMIDE AND DYNCLOFENAC IN RATS WITH EXPERIMENTAL NEUROGENIC PAIN SYNDROME. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(3):331-338. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-3-331-
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ISSN 2524-2350 (Online)
ISSN 2524-2350 (Online)
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