MONOCYTES, MACROPHAGES, DENDRITIC AND MYELOID SUPPRESSOR CELLS: GENESIS, CLASSIFICATION, IMMUNOBIOLOGICAL PROPERTIES
https://doi.org/10.29235/1814-6023-2018-15-3-363-382
Abstract
The article presents the modern data on the most important component of natural immunity – cells of the mononuclear phagocyte system. The questions of origin, the spectrum of expressed markers of differentiation, the classification of monocytes (classical, intermediate, non-classical), macrophages (pro-inflammatory and anti-inflammatory) and dendritic cells (myeloid, plasmacytoid), their immunobiological functions, their role in humoral and T-cell immune responses, anergy and tolerance are considered. The possibility of obtaining cellular immunobiological products (adjuvant and tolerogenic) for immunotherapy of oncological, infectious and autoimmune diseases on their basis is analyzed.
About the Author
L. P. Titov
Republican Scientific and Practical Center for Epidemiology and Microbiology
Belarus
Belarus
Leonid P. Titov – Corresponding Member, D. Sc. (Med.), Professor
23, Filimonov Str., 220114, Minsk
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Titov L.P. MONOCYTES, MACROPHAGES, DENDRITIC AND MYELOID SUPPRESSOR CELLS: GENESIS, CLASSIFICATION, IMMUNOBIOLOGICAL PROPERTIES. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(3):363-382. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-3-363-382
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