STRUCTURAL CHANGES IN THE MICROCIRCULATORY BED OF THE PANCREAS IN RATS WITH EXPERIMENTAL METABOLIC SYNDROME
https://doi.org/10.29235/1814-6023-2018-15-3-347-353
Abstract
A complex histological, histochemical and electron microscopic study of the state of the microcirculatory bed of the pancreas and conjugate transformations in the parenchyma of the organ after modeling the metabolic syndrome using a diet high in fats and carbohydrates was carried out. Spasm of arterioles, the marginal state of leukocytes and the desquamation of endotheliocytes into the lumen of a vessel, the stasis of erythrocytes in capillaries were revealed. The endothelial cells of capillaries had signs of increased transport of substances through the vessel walls: pinocytosis, fenestration, loosening of basal membranes. It was observed that capillaries are filled with shaped blood elements, on the luminal surface of endotheliocytes nuclei are protruded and the cytoplasm outgrowth into the lumen of the vessel is formed. At the same time, glucose oxidation accelerated both in the Krebs cycle and along the glycolytic pathway in the endotheliocytes of the vessels of the microcirculatory bed, indicating that the energy was supplied to the cells at a higher level. Disturbances of microcirculation were accompanied by focal destructive and inflammatory changes in the parenchyma of the organ.
About the Authors
T. E. Kuznetsova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Tatiana E. Kuznetsova – Ph. D. (Biol.), Senior researcher
28, Akademicheskaya Str., 220072, Minsk
E. L. Ryzhkovskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Elena L. Ryzhkovskaya – Senior researcher
28, Akademicheskaya Str., 220072, Minsk
E. I. Kalinovskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Еlena I. Kalinovskaya – Ph. D. (Med.), Head of the Laboratory
28, Akademicheskaya Str., 220072, Minsk
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Review
For citations:
Kuznetsova T.E., Ryzhkovskaya E.L., Kalinovskaya E.I. STRUCTURAL CHANGES IN THE MICROCIRCULATORY BED OF THE PANCREAS IN RATS WITH EXPERIMENTAL METABOLIC SYNDROME. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(3):347-353. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-3-347-353
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