HEALTH STATUS OF CHILDREN BORN BY WOMEN WITH ANTIPHOSPHOLIPID SYNDROME

A. V. Sukalo; V. A. Prilutskaya; M. I. Zoryna

doi:10.29235/1814-6023-2018-15-2-229-243

HEALTH STATUS OF CHILDREN BORN BY WOMEN WITH ANTIPHOSPHOLIPID SYNDROME

A. V. Sukalo, V. A. Prilutskaya, M. I. Zoryna

https://doi.org/10.29235/1814-6023-2018-15-2-229-243

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Abstract

Antiphospholipid syndrome (APS) is an important multidisciplinary problem, especially in obstetrics. The assessment of the health status of children born by mothers with APS is no less significant. Based on the analysis and the systematization of literature from 1987 to 2017, the modern aspects of pathogenesis and diagnostic criteria are presented; both immediate and long-term consequences of mothers’ APS influence on their offspring are considered. APS during pregnancy can lead to an increase in the incidence of pregnancy and passive transmission of antibodies to the fetus, which increases the risk of prematurity, intrauterine growth retardation (IUGR), thrombocytopenia. Antiphospholipid antibodies can influence the nervous system during the embryonic period. Circulation of antibodies in newborns is rarely able to lead to thrombosis, usually against the background of an infectious process and/or hereditary thrombophilia. The health status of newborns, born by mothers with APS, depends on the gestational age, the level of physical development, the interest of brain structures. Further, a long-term follow-up is needed to assess the health status of children in different age periods.

Keywords

newborns, children, pregnancy, antiphospholipid syndrome (APS), diagnostic markers, antiphospholipid antibodies, prematurity, IUGR, neuropsychological development

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For citations:

Sukalo A.V., Prilutskaya V.A., Zoryna M.I. HEALTH STATUS OF CHILDREN BORN BY WOMEN WITH ANTIPHOSPHOLIPID SYNDROME. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(2):229-243. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-2-229-243

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Proceedings of the National Academy of Sciences of Belarus, Medical series

HEALTH STATUS OF CHILDREN BORN BY WOMEN WITH ANTIPHOSPHOLIPID SYNDROME

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