MICROENVIRONMENT OF TUMOR CELLS IN COLON ADENOCARCINOMAS
https://doi.org/10.29235/1814-6023-2018-15-2-222-228
Abstract
An electron microscopic method for analyzing the cells of the stromal component of colon cancer has been applied. During the study, cells of hematogenous and mesenchymal origin with altered ultrastructures were found.
About the Authors
M. A. Derevyanko
Institute of Physiology of the National Academy of Sciences of Belarus.
Russian Federation
Russian Federation
Marina A. Derevyanko – Junior researcher.
28, Akademicheskaya Str., 220072, Minsk.
S. N. Rjabceva
Belarusian State Medical University.
Russian Federation
Russian Federation
Svetlana N. Rjabceva – Ph. D. (Med.), Assistant.
83, Dzerzhinski Ave., 220116, Minsk.
M. V. Fridman
Minsk City Clinical Oncology Center.
Russian Federation
Russian Federation
Mikhail V. Fridman – D. Sc. (Med.), Head of the Laboratory.
64, Nezavisimosti Ave., 220013, Minsk.
I. A. Derevyanko
Institute of Physiology of the National Academy of Sciences of Belarus.
Russian Federation
Russian Federation
Irina A. Derevyanko – Junior researcher.
28, Akademicheskaya Str., 220072, Minsk.
I. V. Zalutskii
Institute of Physiology of the National Academy of Sciences of Belarus.
Russian Federation
Russian Federation
Iosif V. Zalutskii – Corresponding Member, D. Sc. (Med.), Professor, Director.
28, Akademicheskaya Str., 220072, Minsk.
References
1. Labianca R., Nordlinger B., Beretta G. D., Mosconi S., Mandalà M., Cervantes A., Arnold D. Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 2013, vol. 24, iss. 6, pp. vi64–vi72.. DOI: 10.1093/annonc/mdt354
2. Antonenkova N. N., Moiseev P. I., Mashevskii A. A., Yakimovich G. V. Malignant neoplasms in Belarus: premature mortality working-age population, the social loss. Aktual’nye voprosy diagnostiki i lecheniya zlokachestvennykh novoobrazovanii: materialy Respublikanskoi nauchno-prakticheskoi konferentsii, posvyashchennoi 40-letiyu kafedry onkologii [Actual problems of diagnosis and treatment of malignant neoplasms: proceedings of the Republican scientific-practical conference devoted to the 40th anniversary of the Department of Oncology]. Minsk, 2014, pp. 13-14 (in Russian).
3. Sukonko O. G. (ed.) Statistics of cancer diseases in the Republic of Belarus (2002-2011). Minsk, Republican Scientific and Practical Center of Oncology and Medical Radiology, 2012 (in Russian).
4. Adjei I. M., Blanka S. Modulation of the tumor microenvironment for cancer treatment: a biomaterials approach. Journal of Functional Biomaterials, 2015, vol. 6, no. 1, pp. 81-103. DOI: 10.3390/jfb6010081
5. Dudas J. Supportive and rejective functions of tumor stroma on tumor cell growth, survival, and invasivity: the cancer evolution. Frontiers in Frontiers in Oncology, 2015, vol. 5, no. 44, pp. 1-2. DOI:10.3389/fonc.2015.00044
6. Shiga K., Hara M., Nagasaki T., Sato T., Takahashi H., Takeyama H. Cancer-associated fibroblasts: their characteristics and their roles in tumor growth. Cancers, 2015, vol. 7, no. 4, pp. 2443-2458. DOI: 10.3390/cancers7040902
7. Hanchen L., Xueli F., Houghton J. M. Tumor microenvironment: the role of the tumor stroma in cancer. Journal of Cellular Biochemistry, 2007, vol. 101, no. 4, pp. 805-815. DOI:10.1002/jcb.21159
8. Karvonen H. M., Lehtonen S., Sormunen R. T., Harju T. H, Lappi-Blanco E., Bloigu R. S., Kaarteenaho R. Myofibroblasts in interstitial-lung diseases show diverse electron microscopic and invasive features. Laboratory Investigation, 2012, vol. 92, no. 9, pp. 1270-1284. DOI:10.1038/labinvest.2012.95
9. Eyden B. The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine. Journal of Cellular and Molecular Medicine, 2008, vol. 12, no. 1, pp. 22-37. DOI: 10.1111/j.1582-4934.2007.00213.x
Review
For citations:
Derevyanko M.A., Rjabceva S.N., Fridman M.V., Derevyanko I.A., Zalutskii I.V. MICROENVIRONMENT OF TUMOR CELLS IN COLON ADENOCARCINOMAS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(2):222-228. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-2-222-228
Views: 520
Email this article 