EFFECT OF ALPHA-COBRATOXIN ON THE OXIDATIVE STRESS INDUCED BY A SERUM-FREE MEDIUM IN C6 GLIOMA CELLS
https://doi.org/10.29235/1814-6023-2018-15-2-199-206
Abstract
The model studies on C6 glioma cells showed that the role of nicotinic acetylcholine receptors (nAChR) in the regulation of the redox balance varies under different cultivation conditions. In a serum-free medium, the inhibitor of nAXP alpha-cobratoxin alleviates the oxidative stress that is manifested in an increase in the activity of superoxide dismutase and catalase, the level of reduced glutathione and in a decrease in the concentration of malonic dialdehyde.
About the Authors
T. I. Terpinskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Tatiana I. Terpinskaya – Ph. D. (Biol), Leading researcher.
28, Akademicheskaya Str., 220072, Minsk.
A. V. Osipov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
Russian Federation
Russian Federation
Alexey V. Osipov – Ph. D. (Chem.), Senior researcher.
16/10, Miklouho-Maclai Str., 117997, Moscow.
S. B. Kondrashova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Svetlana B. Kondrashova – Senior researcher.
28, Akademicheskaya Str., 220072, Minsk.
V. S. Ulashchyk
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Vladimir S. Ulashchyk – Academician, D. Sc. (Med.), Professor, Chief researcher.
28, Akademicheskaya Str., 220072, Minsk.
Yu. N. Utkin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
Russian Federation
Russian Federation
Yuri N. Utkin – D. Sc. (Chem.), Professor, Chief researcher.
16/10, Miklouho-Maclai Str., 117997, Moscow.
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Review
For citations:
Terpinskaya T.I., Osipov A.V., Kondrashova S.B., Ulashchyk V.S., Utkin Yu.N. EFFECT OF ALPHA-COBRATOXIN ON THE OXIDATIVE STRESS INDUCED BY A SERUM-FREE MEDIUM IN C6 GLIOMA CELLS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(2):199-206. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-2-199-206
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