NEW ALGORITHM FOR LYMPHOMA STAGING BASED ON WHOLE BODY DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING
https://doi.org/10.29235/1814-6023-2018-15-2-179-198
Abstract
A prospective comparative study of the diagnostic efficiency of X-ray computed tomography (CT), ultrasound (US), bone marrow biopsy, osteoscintigraphy and a new safe diagnostic method – whole body diffusion-weighted magnetic resonance imaging (MRI-DWI) in staging lymphoma was conducted. We examined 158 adults including 68 with Hodgkin lymphoma and 90 with non-Hodgkin lymphoma. MRI-DWI demonstrated the highest diagnostic efficiency of lymphoid and bone marrow lesions. For the first time, indications for bone marrow biopsy in patients with lymphoma who underwent whole body MRI-DWI were determined. A new highly effective and safe lymphoma staging algorithm has been developed, including whole body MRI-DWI, US of the spleen, bone marrow biopsy (by indications). The developed algorithm increases a lymphoma staging accuracy with respect to CT without intravenous contrast by 23 %, with respect to CT with intravenous contrast by 17 %. The staging accuracy was 98 %. At the same time, X-ray and radioisotope radiation is not used, intravenous administration of contrast agents and radioactive isotopes is not required, the number of bone marrow biopsies is reduced by 72 %, and a cost of patient examination is reduced.
About the Authors
S. A. Kharuzhyk
N. N. Alexandrov National Cancer Centre.
Russian Federation
Russian Federation
Siarhei A. Kharuzhyk – Ph. D. (Med.), Assistant Professor, doctor of MRI.
223040, Lesnoy, Minsk region.
E. A. Zhavrid
N. N. Alexandrov National Cancer Centre.
Russian Federation
Russian Federation
Edvard A. Zhavrid – D. Sc. (Med.), Chief researcher, Professor.
223040, Lesnoy, Minsk region.
N. V. Sachivko
N. N. Alexandrov National Cancer Centre.
Russian Federation
Russian Federation
Nina V. Sachivko – Ph. D. (Med.), Leading researcher.
223040, Lesnoy, Minsk region.
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For citations:
Kharuzhyk S.A., Zhavrid E.A., Sachivko N.V. NEW ALGORITHM FOR LYMPHOMA STAGING BASED ON WHOLE BODY DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018;15(2):179-198. (In Russ.) https://doi.org/10.29235/1814-6023-2018-15-2-179-198
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