PREDICTION OF SUPRAVENTRICULAR TACHYCARDIA IN PATIENTS UNDERWENT L-THYROXINE SUPPRESSIVE THERAPY
Abstract
It is known that the treatment of patients with thyroid cancer includes a need for suppressive therapy with L-thyroxine. The most frequent complications of subclinical hyperthyroidism arising during treatment are cardiac arrhythmias and, in particular tachycardia.
The goal is to develop a prognostic model for calculating the development of supraventricular tachycardia in young patients (20–44 years) who were subjected to L-thyroxine suppressive therapy for a long time (more than 5 years).
A logit-regression model is proposed for description of an individual prognosis of development of supraventricular tachycardia depending on sex, heart rate variability (CV, SI) and a free thyroxine level. The estimated value of the prognostic indicator Y allows one to identify patients with a high probability of developing a disease and to reduce a dose of L-thyroxine, taking into account the target values of the thyroid-stimulating hormone. The work analyzes the monitored indicators related to a favorable or unfavorable prognosis of development of the disease.
About the Authors
T. A. Mityukova
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Ph. D. (Biol.), Leading researcher
28, Akademicheskaya Str., 220072
I. N. Moroz
Belarusian State Medical University, Minsk
Belarus
Belarus
D. Sc. (Med.), Assistant Professor, Dean
83, Dzerzhynskiy Ave., 220116
T. A. Leonova
Minsk City Clinical Oncological Dispensary, Minsk
Belarus
Belarus
Ph. D. (Med.), Head of the Department
2, Akademicheskaya Str., 220072
J. A. Bezler
Belarusian State Medical University, Minsk
Belarus
Belarus
Ph. D. (Med.), Assistant Professor
83, Dzerzhynskiy Ave., 220116
S. B. Kohan
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Researcher
28, Akademicheskaya Str., 220072
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Review
For citations:
Mityukova T.A., Moroz I.N., Leonova T.A., Bezler J.A., Kohan S.B. PREDICTION OF SUPRAVENTRICULAR TACHYCARDIA IN PATIENTS UNDERWENT L-THYROXINE SUPPRESSIVE THERAPY. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(4):17-23. (In Russ.)
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